Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 2/20 | 0.81 |
| ▸ | PDGFRB | P09619 | 11/20 | 0.65 |
| ▸ | KDR | P35968 | 10/20 | 0.65 |
| ▸ | PRKAA1 | Q13131 | 7/20 | 0.65 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.65 |
| ▸ | PRKAA2 | P54646 | 6/20 | 0.65 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.62 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.62 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.62 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.62 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.62 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.62 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.62 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.62 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.62 |
| ▸ | TLK2 | Q86UE8 | 3/20 | 0.61 |
| ▸ | PLK4 | O00444 | 2/20 | 0.61 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL859965 | 0.90 | ALK (1.00) | ALKPDGFRBKDRPRKAA1FGFR1 | |
| SCHEMBL859966 | 0.90 | ALK (1.00) | ALKPDGFRBKDRPRKAA1FGFR1 | |
| SCHEMBL16085063 | 0.86 | ALK (0.80) | ALKPDGFRBKDRPRKAA1FGFR1 | |
| SCHEMBL13755254 | 0.85 | ALK (0.78) | ALKPDGFRBKDRPRKAA1FGFR1 | |
| SCHEMBL19622467 | 0.83 | ALK (0.75) | ALKPDGFRBKDRPRKAA1FGFR1 | |
| SCHEMBL6587955 | 0.82 | ALK (0.83) | ALKPDGFRBKDRPRKAA1FGFR1 | |
| SCHEMBL3268874 | 0.82 | ALK (0.83) | ALKPDGFRBKDRPRKAA1FGFR1 | |
| SCHEMBL8210235 | 0.82 | ALK (0.83) | ALKPDGFRBKDRPRKAA1FGFR1 | |
| SCHEMBL27919661 | 0.81 | ALK (0.81) | ALKPDGFRBKDRPRKAA1FGFR1 | |
| SCHEMBL1628164 | 0.81 | ALK (0.78) | ALKPDGFRBKDRPRKAA1FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1971333-A4 | AMINO ACID DERIVATIVES OF INDOLINONE BASED PROTEIN KINASE INHIBITORS | SCRIPPS RESEARCH INST (US) | 2009-05-20 | — | — | EP | disclosed |
| US-20090068718-A1 | AMINO ACID DERIVATIVES OF INDOLINONE BASED PROTEIN KINASE INHIBITORS | LIANG CONGXIN | 2009-03-12 | — | — | US | disclosed |
| US-20080269212-A1 | Amino acid derivatives of indolinone based protein kinase inhibitors | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-10-30 | — | — | US | disclosed |
| EP-1971333-A2 | AMINO ACID DERIVATIVES OF INDOLINONE BASED PROTEIN KINASE INHIBITORS | The Scripps Research Institute (US) | 2008-09-24 | — | — | EP | disclosed |
| WO-2007081560-A2 | AMINO ACID DERIVATIVES OF INDOLINONE BASED PROTEIN KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2007-07-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269212-A1 | Amino acid derivatives of indolinone based protein kinase inhibitors | PHKG1, MAP3K20, MKNK1 | ALK 620/4885PDGFRB 817/4885KDR 875/4885 |
| US-20090068718-A1 | AMINO ACID DERIVATIVES OF INDOLINONE BASED PROTEIN KINASE INHIBITORS | PHKG1, MAP3K20, MKNK1 | ALK 620/4885PDGFRB 817/4885KDR 875/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.