SCHEMBL4149563

SCHEMBL4149563

CC(C)(C)NC(=O)c1cc(C2=C(Br)CCC2)cnn1

nearest known ligand 0.34

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
PTGER1 P34995 1/20 0.34
USP30 Q70CQ3 1/20 0.33
ANO1 Q5XXA6 2/20 0.33
CNR2 P34972 2/20 0.32
CNR1 P21554 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13697502 0.81 PTGER1 (0.33) PTGER1
SCHEMBL4155974 0.81 PTGER1 (0.37) PTGER1USP30ANO1CNR2CNR1
SCHEMBL4151043 0.79 PTGER1 (0.43) PTGER1
SCHEMBL13697505 0.71 PTGER1 (0.58) PTGER1ANO1CNR2CNR1
SCHEMBL165757 0.70 CNR2 (0.37) ANO1CNR2CNR1
SCHEMBL4154339 0.69 PTGER1 (0.79) PTGER1
SCHEMBL4170901 0.69 CNR2 (0.37) ANO1CNR2CNR1
SCHEMBL22099923 0.60 CNR2 (0.46) ANO1CNR2
SCHEMBL28247469 0.60 P2RX7 (0.61) USP30ANO1
SCHEMBL2990843 0.60 ANO1 (0.43) ANO1CNR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090227591-A1 Cyclopentene compounds GLAXO GROUP LIMITED (GB) 2009-09-10 US disclosed
US-20090227591-A1 Cyclopentene compounds GLAXO GROUP LIMITED (GB) 2009-09-10 US disclosed
EP-1670763-A1 CYCLOPENTENE COMPOUNDS GLAXO GROUP LIMITED (GB) 2006-06-21 EP disclosed
WO-2005037793-A1 CYCLOPENTENE COMPOUNDS GLAXO GROUP LIMITED (GB) 2005-04-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090227591-A1 Cyclopentene compounds C1R, CYP1B1, ADORA2B PTGER1 246/4885USP30 4407/4885ANO1 2959/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.