Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | RECQL | P46063 | 2/20 | 0.42 |
| ▸ | PLIN1 | O60240 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | PLIN5 | Q00G26 | 2/20 | 0.42 |
| ▸ | ABHD5 | Q8WTS1 | 2/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4149871 | 1.00 | ACHE (0.44) | ACHEHDAC8MAPTRECQLPLIN1 | |
| SCHEMBL17064498 | 0.85 | MAPT (0.52) | ACHEHDAC8MAPTRECQLPLIN1 | |
| SCHEMBL17064497 | 0.85 | MAPT (0.52) | ACHEHDAC8MAPTRECQLPLIN1 | |
| SCHEMBL4158896 | 0.82 | HPGD (0.41) | ACHEMAPTRECQLPLIN1LMNA | |
| SCHEMBL4158903 | 0.82 | HPGD (0.41) | ACHEMAPTRECQLPLIN1LMNA | |
| SCHEMBL22272411 | 0.82 | PADI4 (0.49) | ACHEMAPTRECQLPLIN1LMNA | |
| SCHEMBL4237414 | 0.81 | KDM4E (0.56) | KMT2AMEN1PKM | |
| SCHEMBL4237418 | 0.81 | KDM4E (0.56) | KMT2AMEN1PKM | |
| SCHEMBL19322686 | 0.80 | PADI4 (0.50) | ACHEMAPTRECQLPLIN1LMNA | |
| SCHEMBL5194755 | 0.80 | PADI4 (0.50) | ACHEMAPTRECQLPLIN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090143429-A1 | Quinoline Derivatives as Neurokinin Receptor Antagonists | CRAWFORTH JAMES MICHAEL | 2009-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090143429-A1 | Quinoline Derivatives as Neurokinin Receptor Antagonists | TACR2, TACR1, TACR3 | ACHE 657/4885HDAC8 984/4885MAPT 3729/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.