Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PADI4 | Q9UM07 | 3/20 | 0.50 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | RECQL | P46063 | 2/20 | 0.47 |
| ▸ | PLIN1 | O60240 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | PLIN5 | Q00G26 | 2/20 | 0.47 |
| ▸ | ABHD5 | Q8WTS1 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5194748 | 1.00 | PADI4 (0.50) | PADI4GRIN1GRIN2BMAPTRECQL | |
| SCHEMBL5194755 | 1.00 | PADI4 (0.50) | PADI4GRIN1GRIN2BMAPTRECQL | |
| SCHEMBL22272411 | 0.95 | PADI4 (0.49) | PADI4GRIN1GRIN2BMAPTRECQL | |
| SCHEMBL17064498 | 0.91 | MAPT (0.52) | PADI4MAPTRECQLPLIN1LMNA | |
| SCHEMBL17064497 | 0.91 | MAPT (0.52) | PADI4MAPTRECQLPLIN1LMNA | |
| SCHEMBL7242364 | 0.82 | CHRNA7 (0.49) | MAPTALDH1A1MAPK1NFKB1NFKB2 | |
| SCHEMBL7242365 | 0.82 | CHRNA7 (0.49) | MAPTALDH1A1MAPK1NFKB1NFKB2 | |
| SCHEMBL4149871 | 0.80 | ACHE (0.44) | PADI4MAPTRECQLPLIN1LMNA | |
| SCHEMBL4149874 | 0.80 | ACHE (0.44) | PADI4MAPTRECQLPLIN1LMNA | |
| SCHEMBL7488747 | 0.79 | ALDH1A1 (0.48) | MAPTRECQLPLIN1LMNAPLIN5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170253583-A1 | HETEROAROMATIC CHALCONE DERIVATIVES AND THEIR MEDICAL USE | Universität Wien (AT) | 2017-09-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170253583-A1 | HETEROAROMATIC CHALCONE DERIVATIVES AND THEIR MEDICAL USE | CYP2E1, CYP3A43, CYP11B1 | PADI4 4850/4885GRIN1 4740/4885GRIN2B 4764/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.