Melphalan

Melphalan

SCHEMBL4150935

N[C@@H](Cc1ccc(N(CCCl)CCCl)cc1)C(=O)O.[Cu]

nearest known ligand 0.97

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 6/20 0.97
CYP3A4 P08684 3/20 0.97
ALDH1A1 P00352 3/20 0.97
SMN1; SMN2 Q16637 3/20 0.97
ALOX15 P16050 3/20 0.97
LMNA P02545 3/20 0.97
PTGS1 P23219 3/20 0.97
KMT2A Q03164 2/20 0.97
NFKB1 P19838 2/20 0.97
THPO P40225 2/20 0.97
MAPT P10636 2/20 0.97
PMP22 Q01453 2/20 0.97
TDP1 Q9NUW8 2/20 0.97
KDM4E B2RXH2 2/20 0.97
ABCB11 O95342 1/20 0.97
CHRM2 P08172 1/20 0.97
ADRA2A P08913 1/20 0.97
CHRM1 P11229 1/20 0.97
ACHE P22303 1/20 0.97
OPRM1 P35372 1/20 0.97

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Melphalan SCHEMBL5325132 0.98 HIF1A (1.00) HIF1ACYP3A4ALDH1A1SMN1; SMN2ALOX15
Melphalan SCHEMBL5872 0.98 HIF1A (1.00) HIF1ACYP3A4ALDH1A1SMN1; SMN2ALOX15
(R)-Melphalan SCHEMBL5873 0.98 HIF1A (1.00) HIF1ACYP3A4ALDH1A1SMN1; SMN2ALOX15
Melphalan SCHEMBL563239 0.98 HIF1A (1.00) HIF1ACYP3A4ALDH1A1SMN1; SMN2ALOX15
Sarcolysin SCHEMBL414671 0.98 HIF1A (1.00) HIF1ACYP3A4ALDH1A1SMN1; SMN2ALOX15
Melphalan SCHEMBL2723742 0.97 HIF1A (0.97) HIF1ACYP3A4ALDH1A1SMN1; SMN2ALOX15
Melphalan SCHEMBL41335 0.97 HIF1A (0.97) HIF1ACYP3A4ALDH1A1SMN1; SMN2ALOX15
Sarcolysin SCHEMBL2680958 0.97 HIF1A (0.97) HIF1ACYP3A4ALDH1A1SMN1; SMN2ALOX15
Sarcolysin SCHEMBL29061034 0.97 HIF1A (0.97) HIF1ACYP3A4ALDH1A1SMN1; SMN2ALOX15
Melphalan SCHEMBL11029192 0.97 HIF1A (0.97) HIF1ACYP3A4ALDH1A1SMN1; SMN2ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090105206-A1 Copper Melphalan And Copper Tegafur As Anti-Tumor Agents CAVIRA BIOPHARMACEUTICALS AG (DE) 2009-04-23 US disclosed
US-20090105206-A1 Copper Melphalan And Copper Tegafur As Anti-Tumor Agents CAVIRA BIOPHARMACEUTICALS AG (DE) 2009-04-23 US disclosed
EP-1814536-A1 COPPER MELPHALAN AND COPPER TEGAFUR USED AS ANTI-TUMORAL AGENTS Gavira Biopharmaceuticals AG (DE) 2007-08-08 EP disclosed
WO-2006056449-A1 COPPER MELPHALAN AND COPPER TEGAFUR USED AS ANTI-TUMORAL AGENTS CAVIRA BIOPHARMACEUTICALS AG (DE) 2006-06-01 WO disclosed