Melphalan

Melphalan

SCHEMBL5872

N[C@@H](Cc1ccc(N(CCCl)CCCl)cc1)C(=O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 6/20 1.00
CYP3A4 P08684 3/20 1.00
ALDH1A1 P00352 3/20 1.00
SMN1; SMN2 Q16637 3/20 1.00
ALOX15 P16050 3/20 1.00
LMNA P02545 3/20 1.00
PTGS1 P23219 3/20 1.00
KMT2A Q03164 2/20 1.00
NFKB1 P19838 2/20 1.00
THPO P40225 2/20 1.00
MAPT P10636 2/20 1.00
PMP22 Q01453 2/20 1.00
TDP1 Q9NUW8 2/20 1.00
KDM4E B2RXH2 2/20 1.00
ABCB11 O95342 1/20 1.00
CHRM2 P08172 1/20 1.00
ADRA2A P08913 1/20 1.00
CHRM1 P11229 1/20 1.00
ACHE P22303 1/20 1.00
OPRM1 P35372 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Sarcolysin SCHEMBL414671 1.00 HIF1A (1.00) HIF1ACYP3A4ALDH1A1SMN1; SMN2ALOX15
(R)-Melphalan SCHEMBL5873 1.00 HIF1A (1.00) HIF1ACYP3A4ALDH1A1SMN1; SMN2ALOX15
Melphalan SCHEMBL5325132 1.00 HIF1A (1.00) HIF1ACYP3A4ALDH1A1SMN1; SMN2ALOX15
Melphalan SCHEMBL563239 1.00 HIF1A (1.00) HIF1ACYP3A4ALDH1A1SMN1; SMN2ALOX15
Melphalan SCHEMBL41335 0.98 HIF1A (0.97) HIF1ACYP3A4ALDH1A1SMN1; SMN2ALOX15
Melphalan SCHEMBL2723742 0.98 HIF1A (0.97) HIF1ACYP3A4ALDH1A1SMN1; SMN2ALOX15
Sarcolysin SCHEMBL2680958 0.98 HIF1A (0.97) HIF1ACYP3A4ALDH1A1SMN1; SMN2ALOX15
Melphalan SCHEMBL4150935 0.98 HIF1A (0.97) HIF1ACYP3A4ALDH1A1SMN1; SMN2ALOX15
Sarcolysin SCHEMBL29061034 0.98 HIF1A (0.97) HIF1ACYP3A4ALDH1A1SMN1; SMN2ALOX15
Melphalan SCHEMBL11029192 0.98 HIF1A (0.97) HIF1ACYP3A4ALDH1A1SMN1; SMN2ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 189803 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4748859-A2 CHEMICALLY AND PHOTOCHEMICALLY INITIATED CELL MEMBRANE BLEBBING TO INDUCE CELL VESICLE PRODUCTION, MODIFICATIONS THEREOF, AND USES THEREOF The Regents of the University of California (US) 2026-05-27 EP claimed
EP-3607938-B1 PHARMACEUTICAL COMPOSITION SOVIC BRKICIC LJILJANA (HR) 2026-05-27 EP claimed
EP-4748376-A2 METHODS OF TREATING CANCERS AND ENHANCING EFFICACY OF T CELL REDIRECTING THERAPEUTICS Janssen Biotech, Inc. (US) 2026-05-27 EP claimed
CN-122094711-A Methods for treating multiple myeloma comprising anti-CD 38 antibodies in combination with bortezomib, lenalidomide and dexamethasone 2026-05-26 CN claimed
CN-116209439-B Cereblon protein modulators Saint Jude Children's Research Hospital Ltd. (US) 2026-05-26 CN claimed
CN-122070936-A Nanometer material based on supermolecule polypeptide-drug coupling prodrug, and preparation method and application thereof 中国医学科学院生物医学工程研究所 2026-05-22 CN claimed
US-20260137650-A1 MODULATORS OF RAR RELATED ORPHAN RECEPTORS (RORs) 11949098 CANADA INC (CA) 2026-05-21 US claimed
US-20260137686-A1 SOLID PHARMACEUTICAL FORMULATION OF PARP INHIBITORS AND USE THEREOF IMPACT THERAPEUTICS SHANGHAI INC (CN) 2026-05-21 US claimed
WO-2026106917-A1 EDIBLE TRANSMUCOSAL DRUG DELIVERY METHOD USING AN INTERMEDIATE CAPSULE AS A TEMPORARY VESSEL BioPhysics Pharma, Inc. (US) 2026-05-21 WO claimed
WO-2026105121-A1 ANTICANCER FORMULATIONS AND USES THEREOF INTRAGEL THERAPEUTICS LTD. (IL) 2026-05-21 WO claimed
WO-1984001506-A1 PHARMACEUTICAL PREPARATIONS FOR USE IN ANTITUMOUR THERAPY UNIV BIRMINGHAM (GB) 1984-04-26 WO claimed
EP-0095906-A1 Improvements relating to compounds useful in radiotherapy or chemotherapy NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) 1983-12-07 EP claimed
WO-1983003968-A1 BRAIN-SPECIFIC DRUG DELIVERY UNIVERSITY OF FLORIDA (US) 1983-11-24 WO claimed
US-4401592-A REACTION PRODUCT OF AN ANTIBODY WITH AN ANTIBIOTIC, ANTIMETABOLIC SUBSTANCE OR ALKYLATING AGENT KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1983-08-30 US claimed
EP-0083600-A1 Use of alkaloid derivatives for the manufacture of a medicament for the strengthening of the immune system and for the treatment of viral, bacterial and fungal infections. NOWICKY WASSILI 1983-07-20 EP claimed
WO-1983000486-A1 METHOD FOR THE DIAGNOSTIC AND THE THERAPEUTIC TREATMENT OF TUMORS AND/OR INFECTIOUS DISEASES OF ALL SORTS BY THE USE OF ALKALOID COMPOSITIONS OR THE SALTS THEREOF NOWICKY, WASSYL 1983-02-17 WO claimed
EP-0064040-A1 Therapeutically active disulphide compounds and their use PHARMACIA AKTIEBOLAG (SE) 1982-11-03 EP claimed
WO-1982003395-A1 THERAPEUTICALLY ACTIVE COMPOUND AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME PHARMACIA AB (SE) 1982-10-14 WO claimed
EP-0010964-A1 Ravidomycin, process of preparation and pharmaceutical compositions containing same AYERST, MCKENNA AND HARRISON INC. (CA) 1980-05-14 EP claimed
US-4017471-A ANTITUMOR AGENT G. D. SEARLE & CO. (EN) 1977-04-12 US claimed