(R)-Melphalan

(R)-Melphalan

SCHEMBL5873

N[C@H](Cc1ccc(N(CCCl)CCCl)cc1)C(=O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 6/20 1.00
CYP3A4 P08684 3/20 1.00
ALDH1A1 P00352 3/20 1.00
SMN1; SMN2 Q16637 3/20 1.00
ALOX15 P16050 3/20 1.00
LMNA P02545 3/20 1.00
PTGS1 P23219 3/20 1.00
KMT2A Q03164 2/20 1.00
NFKB1 P19838 2/20 1.00
THPO P40225 2/20 1.00
MAPT P10636 2/20 1.00
PMP22 Q01453 2/20 1.00
TDP1 Q9NUW8 2/20 1.00
KDM4E B2RXH2 2/20 1.00
ABCB11 O95342 1/20 1.00
CHRM2 P08172 1/20 1.00
ADRA2A P08913 1/20 1.00
CHRM1 P11229 1/20 1.00
ACHE P22303 1/20 1.00
OPRM1 P35372 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Sarcolysin SCHEMBL414671 1.00 HIF1A (1.00) HIF1ACYP3A4ALDH1A1SMN1; SMN2ALOX15
Melphalan SCHEMBL5872 1.00 HIF1A (1.00) HIF1ACYP3A4ALDH1A1SMN1; SMN2ALOX15
Melphalan SCHEMBL5325132 1.00 HIF1A (1.00) HIF1ACYP3A4ALDH1A1SMN1; SMN2ALOX15
Melphalan SCHEMBL563239 1.00 HIF1A (1.00) HIF1ACYP3A4ALDH1A1SMN1; SMN2ALOX15
Melphalan SCHEMBL41335 0.98 HIF1A (0.97) HIF1ACYP3A4ALDH1A1SMN1; SMN2ALOX15
Melphalan SCHEMBL2723742 0.98 HIF1A (0.97) HIF1ACYP3A4ALDH1A1SMN1; SMN2ALOX15
Sarcolysin SCHEMBL2680958 0.98 HIF1A (0.97) HIF1ACYP3A4ALDH1A1SMN1; SMN2ALOX15
Melphalan SCHEMBL4150935 0.98 HIF1A (0.97) HIF1ACYP3A4ALDH1A1SMN1; SMN2ALOX15
Sarcolysin SCHEMBL29061034 0.98 HIF1A (0.97) HIF1ACYP3A4ALDH1A1SMN1; SMN2ALOX15
Melphalan SCHEMBL11029192 0.98 HIF1A (0.97) HIF1ACYP3A4ALDH1A1SMN1; SMN2ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 24929 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260109699-A1 AZOLE DERIVATIVES AS SHP2 INHIBITORS IRBM S.P.A. (IT) 2026-04-23 US claimed
US-20260108476-A1 2,4 DNP and Prodrugs Thereof for Treatment of Cancer MITOCHON PHARMACEUTICALS, INC. (US) 2026-04-23 US claimed
EP-4729063-A2 TREATMENT OF CANCER USING COENZYME Q10 COMBINATION THERAPIES BPGbio, Inc. (US) 2026-04-22 EP claimed
US-20260076872-A1 POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME SIO2 MEDICAL PRODUCTS LLC (US) 2026-03-19 US claimed
US-12577255-B2 MDM2-based modulators of proteolysis and associated methods of use ARVINAS OPERATIONS, INC. (US) 2026-03-17 US claimed
EP-4704832-A2 BIFUNCTIONAL SMALL MOLECULES TO TARGET THE SELECTIVE DEGRADATION OF CIRCULATING PROTEINS Biohaven Therapeutics Ltd. (VG) 2026-03-11 EP claimed
US-20260022117-A1 COMPOUNDS AND METHODS FOR THE ENHANCED DEGRADATION OF TARGETED PROTEINS ARVINAS OPERATIONS INC (US) 2026-01-22 US claimed
EP-4674432-A1 COMBINATION DRUG CONTAINING CD20/CD47 BLOCKING BIFUNCTIONAL FUSION PROTEIN, AND USE THEREOF Shanghai JMT-Bio Technology Co., Ltd. (CN) 2026-01-07 EP claimed
US-12485178-B2 Bifunctional small molecules to target the selective degradation of circulating proteins YALE UNIVERSITY (US) 2025-12-02 US claimed
EP-4644418-A1 NANOBODY TARGETING BCMA, CHIMERIC ANTIGEN RECEPTOR AND USE THEREOF Hebei Senlang Biotechnology Co. Ltd. (CN) 2025-11-05 EP claimed
WO-1991002062-A2 C-ERBB-2 EXTERNAL DOMAIN: GP75 TRITON BIOSCIENCES, INC. (US) 1991-02-21 WO claimed
EP-0353295-A4 NOVEL AND IMPROVED ANTIBODIES FOR SITE SPECIFIC ATTACHMENT OF COMPOUNDS. CYTOGEN CORP (US) 1990-06-26 EP claimed
EP-0353295-A1 NOVEL AND IMPROVED ANTIBODIES FOR SITE SPECIFIC ATTACHMENT OF COMPOUNDS. CYTOGEN CORP (US) 1990-02-07 EP claimed
WO-1989007114-A1 NOVEL AND IMPROVED ANTIBODIES FOR SITE SPECIFIC ATTACHMENT OF COMPOUNDS CYTOGEN CORPORATION (US) 1989-08-10 WO claimed
US-4743590-A METHIONINE, 3-(P-FLUOROPHENYL)ALANINE, 3-(M-BIS(2-CHLOROETHYL)AMINOPHENYL)ALANINE DEBARBIERI AUGUSTO (IT) 1988-05-10 US claimed
US-4671958-A Antibody conjugates for the delivery of compounds to target sites CYTOGEN CORPORATION (US) 1987-06-09 US claimed
EP-0187547-A2 Synthetic polymeric drugs Ceskoslovenska akademie ved (CS) 1986-07-16 EP claimed
EP-0064040-B1 THERAPEUTICALLY ACTIVE DISULPHIDE COMPOUNDS AND THEIR USE PHARMACIA AKTIEBOLAG (SE) 1985-08-28 EP claimed
EP-0064040-A1 Therapeutically active disulphide compounds and their use PHARMACIA AKTIEBOLAG (SE) 1982-11-03 EP claimed
WO-1982003395-A1 THERAPEUTICALLY ACTIVE COMPOUND AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME PHARMACIA AB (SE) 1982-10-14 WO claimed