Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 6/20 | 0.59 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.44 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.44 |
| ▸ | WNT1 | P04628 | 4/20 | 0.41 |
| ▸ | CLK2 | P49760 | 4/20 | 0.39 |
| ▸ | CLK3 | P49761 | 4/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3800944 | 0.96 | HPGDS (0.59) | HPGDSTGFBR1TGFBR2WNT1CLK2 | |
| SCHEMBL3672577 | 0.90 | TGFBR1 (0.46) | HPGDSTGFBR1TGFBR2WNT1CLK2 | |
| SCHEMBL3724304 | 0.90 | TGFBR1 (0.46) | HPGDSTGFBR1TGFBR2WNT1CLK2 | |
| SCHEMBL3722355 | 0.89 | TGFBR1 (0.46) | HPGDSTGFBR1TGFBR2WNT1CLK2 | |
| SCHEMBL3665916 | 0.88 | HPGDS (0.56) | HPGDSTGFBR1TGFBR2WNT1CLK2 | |
| SCHEMBL4158356 | 0.87 | TGFBR1 (0.47) | HPGDSTGFBR1TGFBR2WNT1 | |
| SCHEMBL4154301 | 0.84 | FYN (0.47) | HPGDSTGFBR1TGFBR2MAPK8 | |
| SCHEMBL3719671 | 0.83 | TGFBR1 (0.41) | HPGDSTGFBR1TGFBR2MAPK14HDAC1 | |
| SCHEMBL4164001 | 0.82 | HPGDS (0.66) | HPGDSTGFBR1TGFBR2WNT1 | |
| SCHEMBL4161445 | 0.82 | KDR (0.48) | HPGDSTGFBR1TGFBR2WNT1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101970435-B | Pyrrolopyrimidines and pyrrolopyridines | NOVARTIS AG | 2014-07-02 | — | — | CN | claimed |
| US-8314112-B2 | Pyrrolopyrimidines and pyrrolopyridines | NOVARTIS AG (CH) | 2012-11-20 | — | — | US | claimed |
| CN-101970435-A | Pyrrolopyrimidines and pyrrolopyridines | NOVARTIS AG | 2011-02-09 | — | — | CN | claimed |
| US-20090181941-A1 | Pyrrolopyrimidines and Pyrrolopyridines | NOVARTIS AG (CH) | 2009-07-16 | — | — | US | claimed |
| CN-101970435-B | Pyrrolopyrimidines and pyrrolopyridines | NOVARTIS AG | 2014-07-02 | — | — | CN | disclosed |
| US-8314112-B2 | Pyrrolopyrimidines and pyrrolopyridines | NOVARTIS AG (CH) | 2012-11-20 | — | — | US | disclosed |
| CN-101970435-A | Pyrrolopyrimidines and pyrrolopyridines | NOVARTIS AG | 2011-02-09 | — | — | CN | disclosed |
| US-20090181941-A1 | Pyrrolopyrimidines and Pyrrolopyridines | NOVARTIS AG (CH) | 2009-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181941-A1 | Pyrrolopyrimidines and Pyrrolopyridines | ALK, ACVR1, PTPN4 | HPGDS 1987/4885TGFBR1 128/4885TGFBR2 443/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.