Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 17/20 | 0.51 |
| ▸ | NR1I2 | O75469 | 5/20 | 0.51 |
| ▸ | CFTR | P13569 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4138622 | 0.88 | CASR (0.63) | CASRNR1I2 | |
| SCHEMBL4152394 | 0.83 | CASR (0.52) | CASRNR1I2 | |
| SCHEMBL3382480 | 0.83 | CASR (0.70) | CASRNR1I2 | |
| SCHEMBL4144973 | 0.77 | CASR (0.54) | CASRNR1I2 | |
| SCHEMBL13851663 | 0.76 | CASR (0.87) | CASRNR1I2 | |
| SCHEMBL3382630 | 0.75 | CASR (0.69) | CASRNR1I2 | |
| SCHEMBL4143882 | 0.75 | CASR (0.67) | CASRNR1I2 | |
| SCHEMBL13851660 | 0.74 | CASR (0.66) | CASRNR1I2 | |
| SCHEMBL3381170 | 0.74 | CASR (0.67) | CASRNR1I2 | |
| SCHEMBL3380704 | 0.73 | CASR (0.66) | CASRNR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090137557-A1 | Calcilytic Compounds | SMITHKLINE BEECHAM CORPORATION | 2009-05-28 | — | — | US | claimed |
| US-20090137557-A1 | Calcilytic Compounds | SMITHKLINE BEECHAM CORPORATION | 2009-05-28 | — | — | US | disclosed |
| US-20090137557-A1 | Calcilytic Compounds | SMITHKLINE BEECHAM CORPORATION | 2009-05-28 | — | — | US | disclosed |
| US-20090137557-A1 | Calcilytic Compounds | SMITHKLINE BEECHAM CORPORATION | 2009-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137557-A1 | Calcilytic Compounds | CALCR, SOST, CALCB | CASR 12/4885NR1I2 3373/4885CFTR 1963/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.