Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.36 |
| ▸ | EBP | Q15125 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4151596 | 1.00 | HDAC1 (0.43) | HDAC1HDAC6SMN1; SMN2LMNAPROKR1 | |
| SCHEMBL13563960 | 0.95 | SMN1; SMN2 (0.40) | HDAC1HDAC6SMN1; SMN2LMNAPROKR1 | |
| SCHEMBL13563961 | 0.92 | NOTUM (0.39) | HDAC1HDAC6SMN1; SMN2LMNAPROKR1 | |
| SCHEMBL1689938 | 0.91 | HDAC1 (0.49) | HDAC1HDAC6SMN1; SMN2 | |
| SCHEMBL1689945 | 0.91 | HDAC1 (0.49) | HDAC1HDAC6SMN1; SMN2 | |
| SCHEMBL10253695 | 0.89 | HDAC1 (0.45) | HDAC1HDAC6SMN1; SMN2LMNASIGMAR1 | |
| SCHEMBL13968936 | 0.88 | NOTUM (0.42) | HDAC1HDAC6SMN1; SMN2LMNAPROKR1 | |
| SCHEMBL1689746 | 0.86 | SMN1; SMN2 (0.38) | HDAC1HDAC6SMN1; SMN2LMNAPROKR1 | |
| SCHEMBL1689743 | 0.86 | SMN1; SMN2 (0.38) | HDAC1HDAC6SMN1; SMN2LMNAPROKR1 | |
| SCHEMBL895335 | 0.85 | SMN1; SMN2 (0.38) | HDAC1HDAC6SMN1; SMN2LMNAPROKR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8846907-B2 | Spiro-condensed indoline derivatives as pesticides | SYNGENTA CROP PROTECTION LLC (US) | 2014-09-30 | — | — | US | disclosed |
| US-20130046091-A1 | SPIRO-CONDENSED INDOLINE DERIVATIVES AS PESTICIDES | SYNGENTA CROP PROTECTION LLC (US) | 2013-02-21 | — | — | US | disclosed |
| US-8299058-B2 | Spiro-condensed indoline derivatives as pesticides | SYNGENTA CROP PROTECTION LLC (US) | 2012-10-30 | — | — | US | disclosed |
| US-20090042859-A1 | SPIRO-CONDENSED INDOLINE DERIVATIVES AS PESTICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2009-02-12 | — | — | US | disclosed |
| EP-1697376-B1 | SPIRO-CONDENSED INDOLINE DERIVATIVES AS PESTICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2008-06-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042859-A1 | SPIRO-CONDENSED INDOLINE DERIVATIVES AS PESTICIDES | CHRM1, CHRM2, RO60 | HDAC1 222/4885HDAC6 416/4885SMN1; SMN2 2005/4885 |
| US-20130046091-A1 | SPIRO-CONDENSED INDOLINE DERIVATIVES AS PESTICIDES | CHRM1, CHRM2, CHRM3 | HDAC1 275/4885HDAC6 683/4885SMN1; SMN2 1642/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.