Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | CFTR | P13569 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3936860 | 0.83 | ASPH (0.49) | MEN1KMT2AGAAKDM4ENOTUM | |
| SCHEMBL12302078 | 0.81 | MAPT (0.55) | MAPTCFTRMEN1KMT2AKDM4E | |
| SCHEMBL15038347 | 0.79 | MAPT (0.60) | MAPTCFTRGAAKDM4ENOTUM | |
| SCHEMBL1819192 | 0.79 | MAPT (0.53) | MAPTCFTRMEN1KMT2AKDM4E | |
| SCHEMBL473983 | 0.79 | MAPT (0.60) | MAPTCFTRMEN1KMT2AGAA | |
| SCHEMBL3780170 | 0.79 | MAPT (0.63) | MAPTCFTRMEN1KMT2AGAA | |
| SCHEMBL6377058 | 0.77 | MAPT (0.51) | MAPTCFTRMEN1KMT2AKDM4E | |
| SCHEMBL13080475 | 0.74 | CYP1A2 (0.38) | MEN1KMT2AGAAKDM4EALDH1A1 | |
| SCHEMBL1110884 | 0.73 | CFTR (0.48) | MAPTCFTRMEN1KMT2AGAA | |
| SCHEMBL4925877 | 0.73 | CFTR (0.47) | MAPTCFTRGAAKDM4ENOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8481745-B2 | N-(aminoheteroaryl)-1H-indole-2-carboxamide derivatives, preparation thereof and therapeutic use therof | SANOFI (FR) | 2013-07-09 | — | — | US | disclosed |
| US-20120264944-A1 | N-(AMINOHETEROARYL)-1H-INDOLE-2-CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEROF | SANOFI (FR) | 2012-10-18 | — | — | US | disclosed |
| US-8227489-B2 | N-(aminoheteroaryl)-1H-indole-2-carboxamide derivatives, preparation thereof and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2012-07-24 | — | — | US | disclosed |
| US-20090156809-A1 | N-(AMINOHETEROARYL)-1H-INDOLE-2-CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120264944-A1 | N-(AMINOHETEROARYL)-1H-INDOLE-2-CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEROF | IDO2, IDO1, IKZF3 | MAPT 2838/4885CFTR 2757/4885MEN1 1577/4885 |
| US-20090156809-A1 | N-(AMINOHETEROARYL)-1H-INDOLE-2-CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | IDO1, IDO2, CNKSR1 | MAPT 3749/4885CFTR 3059/4885MEN1 2402/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.