Sugi Predict

Sugi Predict / Compounds / SCHEMBL473983

SCHEMBL473983

SCHEMBL473983

COC(=O)c1cnc(Cl)cc1C(F)(F)F

nearest known ligand 0.60

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 2/20 0.60
▸ CFTR P13569 4/20 0.46
▸ MEN1 O00255 1/20 0.44
▸ KMT2A Q03164 1/20 0.44
▸ KDM4E B2RXH2 2/20 0.44
▸ MAPK1 P28482 2/20 0.44
▸ NPC1 O15118 1/20 0.44
▸ ALDH1A1 P00352 1/20 0.44
▸ POLB P06746 1/20 0.43
▸ GAA P10253 3/20 0.42
▸ NPSR1 Q6W5P4 1/20 0.42
▸ NOTUM Q6P988 3/20 0.41
▸ ATF1 P18846 1/20 0.40
▸ NFKB1 P19838 1/20 0.40
▸ MCOLN3 Q8TDD5 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29850455 0.88 MAPT (0.50) MAPTCFTRMEN1KMT2AKDM4E
SCHEMBL473889 0.88 MAPT (0.50) MAPTCFTRMEN1KMT2AKDM4E
SCHEMBL17796812 0.85 MAPT (0.45) MAPTMEN1KMT2APOLBGAA
SCHEMBL12302078 0.84 MAPT (0.55) MAPTCFTRMEN1KMT2AKDM4E
SCHEMBL18795052 0.84 KDM4E (0.52) MAPTMEN1KMT2AKDM4EMAPK1
SCHEMBL21598904 0.82 MAPT (0.41) MAPTMEN1KMT2AALDH1A1POLB
SCHEMBL1929528 0.82 ASPH (0.42) MAPTMEN1KMT2AKDM4EALDH1A1
SCHEMBL3780170 0.81 MAPT (0.63) MAPTCFTRMEN1KMT2AKDM4E
SCHEMBL15038347 0.81 MAPT (0.60) MAPTCFTRKDM4EMAPK1NPC1
SCHEMBL1819192 0.81 MAPT (0.53) MAPTCFTRMEN1KMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 191 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12570642-B2 GLP-IR modulating compounds GILEAD SCIENCES, INC. (US) 2026-03-10 — — US disclosed
EP-4691554-A2 GLP-1R MODULATING COMPOUNDS Gilead Sciences, Inc. (US) 2026-02-11 — — EP disclosed
EP-4271672-B1 CARBOXY-BENZIMIDAZOLE GLP-1R MODULATING COMPOUNDS GILEAD SCIENCES INC (US) 2025-12-03 — — EP disclosed
WO-2025096957-A1 RAS-PI3K INHIBITORS AND USES THEREOF VIVIDION THERAPEUTICS, INC. (US) 2025-05-08 — — WO disclosed
WO-2025072451-A1 RAS-PI3K INHIBITORS FOR THE TREATMENT OF CANCER AND IMMUNOLOGICAL DISEASES VIVIDION THERAPEUTICS, INC. (US) 2025-04-03 — — WO disclosed
US-12264147-B2 Substituted carboxamides as inhibitors of WDR5 protein-protein binding Propellon Therapeutics Inc. (CA) 2025-04-01 — — US disclosed
US-20240199589-A1 GLP-1R MODULATING COMPOUNDS GILEAD SCIENCES, INC. 2024-06-20 — — US disclosed
US-20240158392-A1 SMALL MOLECULE INHIBITORS OF SALT INDUCIBLE KINASES JANSSEN RESEARCH & DEVELOPMENT, LLC 2024-05-16 — — US disclosed
US-11858918-B2 GLP-1R modulating compounds GILEAD SCIENCES, INC. (US) 2024-01-02 — — US disclosed
US-11858918-B2 GLP-1R modulating compounds GILEAD SCIENCES, INC. (US) 2024-01-02 — — US disclosed
WO-2005049606-A1 HETEROARYL DERIVATIVES AS PPAR ACTIVATORS F. HOFFMANN-LA ROCHE AG (CH) 2005-06-02 — — WO disclosed
EP-1114030-B1 PYRIDINE KETONES USEFUL AS HERBICIDES SYNGENTA PARTICIPATIONS AG (CH) 2005-06-01 — — EP disclosed
US-20050096353-A1 Indolyl and dihydroindolyl derivatives, their manufacture and use as pharmaceutical agents HOFFMANN-LA ROCHE INC. 2005-05-05 — — US disclosed
US-20050096337-A1 Phenyl derivatives, their manufacture and use as pharmaceutical agents HOFFMANN-LA ROCHE INC. 2005-05-05 — — US disclosed
WO-2004029026-A1 PYRIDINE DERIVATIVES AS CB2 RECEPTOR MODULATORS GLAXO GROUP LIMITED (GB) 2004-04-08 — — WO disclosed
WO-2004029027-A1 PYRIDINE DERIVATIVES AS CB2 RECEPTOR MODULATORS GLAXO GROUP LIMITED (GB) 2004-04-08 — — WO disclosed
US-6498125-B2 Pyridine ketones useful as herbicides SYNGENTA PARTICIPATIONS AG (CH) 2002-12-24 — — US disclosed
US-20020016345-A1 Pyridine ketones useful as herbicides SYNGENTA PARTICIPATIONS AG (CH) 2002-02-07 — — US disclosed
EP-1114030-A1 PYRIDINE KETONES USEFUL AS HERBICIDES Syngenta Participations AG (CH) 2001-07-11 — — EP disclosed
WO-2000015615-A1 PYRIDINE KETONES USEFUL AS HERBICIDES SYNGENTA PARTICIPATIONS AG (CH) 2000-03-23 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240158392-A1 SMALL MOLECULE INHIBITORS OF SALT INDUCIBLE KINASES SIK2, SIK1, SGK2 MAPT 718/4885CFTR 3411/4885MEN1 3397/4885
US-12264147-B2 Substituted carboxamides as inhibitors of WDR5 protein-protein binding WDR5, WDR82, WDR1 MAPT 2234/4885CFTR 3394/4885MEN1 3660/4885
US-20050096337-A1 Phenyl derivatives, their manufacture and use as pharmaceutical agents PPARD, PPARA, PPARG MAPT 2957/4885CFTR 162/4885MEN1 4086/4885
US-20020016345-A1 Pyridine ketones useful as herbicides DDT, PDHA1, IDH2 MAPT 3388/4885CFTR 3189/4885MEN1 4037/4885
US-11858918-B2 GLP-1R modulating compounds GLP1R, GIPR, GPR119 MAPT 3314/4885CFTR 136/4885MEN1 1966/4885
US-20240199589-A1 GLP-1R MODULATING COMPOUNDS GLP1R, GIPR, GPR119 MAPT 3314/4885CFTR 136/4885MEN1 1966/4885
US-12570642-B2 GLP-IR modulating compounds GLP1R, GIPR, GPR119 MAPT 4046/4885CFTR 52/4885MEN1 1820/4885
US-20050096353-A1 Indolyl and dihydroindolyl derivatives, their manufacture and use as pharmaceutical agents PPARD, PPARA, PPARG MAPT 2519/4885CFTR 857/4885MEN1 4065/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.