Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 2/20 | 0.41 |
| ▸ | TPH1 | P17752 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.38 |
| ▸ | GLS | O94925 | 1/20 | 0.38 |
| ▸ | NLN | Q9BYT8 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | FCER2 | P06734 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4151722 | 0.83 | SIRT2 (0.41) | MCHR1TPH1CES1ATG4BGLS | |
| Trifluoroacetic Acid SCHEMBL4156590 | 0.81 | SIRT2 (0.41) | MCHR1TPH1CES1GLSHDAC1 | |
| Trifluoroacetic Acid SCHEMBL4163740 | 0.79 | MCHR1 (0.41) | MCHR1CES1ATG4BHDAC1HDAC2 | |
| Trifluoroacetic Acid SCHEMBL4166172 | 0.78 | SIRT2 (0.41) | MCHR1TPH1CES1GLSHDAC1 | |
| Trifluoroacetic Acid SCHEMBL4166154 | 0.77 | SIRT2 (0.38) | MCHR1TPH1CES1HDAC1HDAC2 | |
| Trifluoroacetic Acid SCHEMBL4162610 | 0.77 | HDAC1 (0.34) | MCHR1TPH1CES1HDAC1HDAC2 | |
| Trifluoroacetic Acid SCHEMBL4165163 | 0.75 | SIRT2 (0.38) | MCHR1TPH1CES1GLSHDAC1 | |
| SCHEMBL4156445 | 0.75 | CES1 (0.59) | CES1HDAC1HDAC2HDAC3HDAC4 | |
| Trifluoroacetic Acid SCHEMBL4151859 | 0.75 | MCHR1 (0.42) | MCHR1GLSHDAC1CYP1A2 | |
| Trifluoroacetic Acid SCHEMBL4162623 | 0.75 | SIRT2 (0.38) | MCHR1TPH1CES1GLSHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090054448-A1 | Amino Acid Derivatives as Histone Deacetylase (HDAC) Inhibitors | JONES PHILIP | 2009-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054448-A1 | Amino Acid Derivatives as Histone Deacetylase (HDAC) Inhibitors | HDAC5, HDAC1, HDAC11 | MCHR1 3532/4885TPH1 101/4885CES1 1925/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.