Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 6/20 | 0.42 |
| ▸ | F11 | P03951 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | GLS | O94925 | 1/20 | 0.34 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5126720 | 0.80 | MCHR1 (0.41) | MCHR1ALDH1A1NPC1USP2CYP1A2 | |
| Trifluoroacetic Acid SCHEMBL4151861 | 0.79 | NPC1 (0.33) | ALDH1A1NPC1USP2CYP1A2CYP2D6 | |
| Trifluoroacetic Acid SCHEMBL4163740 | 0.77 | MCHR1 (0.41) | MCHR1HDAC1 | |
| SCHEMBL4162548 | 0.77 | NPC1 (0.43) | F11ALDH1A1NPC1CYP1A2CYP2D6 | |
| SCHEMBL4151724 | 0.75 | MCHR1 (0.41) | MCHR1CYP1A2GLSHDAC1 | |
| Trifluoroacetic Acid SCHEMBL4156590 | 0.74 | SIRT2 (0.41) | MCHR1CYP1A2GLSHDAC1 | |
| Trifluoroacetic Acid SCHEMBL4166172 | 0.73 | SIRT2 (0.41) | MCHR1GLSHDAC1SCN9A | |
| Trifluoroacetic Acid SCHEMBL4166154 | 0.72 | SIRT2 (0.38) | MCHR1HDAC1SCN9A | |
| SCHEMBL4151722 | 0.72 | SIRT2 (0.41) | MCHR1CYP1A2GLSHDAC1 | |
| Trifluoroacetic Acid SCHEMBL4165163 | 0.71 | SIRT2 (0.38) | MCHR1GLSHDAC1SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090054448-A1 | Amino Acid Derivatives as Histone Deacetylase (HDAC) Inhibitors | JONES PHILIP | 2009-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054448-A1 | Amino Acid Derivatives as Histone Deacetylase (HDAC) Inhibitors | HDAC5, HDAC1, HDAC11 | MCHR1 3532/4885F11 2929/4885ALDH1A1 320/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.