Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | TET3 | O43151 | 1/20 | 0.36 |
| ▸ | FBXL19 | Q6PCT2 | 1/20 | 0.36 |
| ▸ | CXXC5 | Q7LFL8 | 1/20 | 0.36 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.36 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.36 |
| ▸ | CXXC4 | Q9H2H0 | 1/20 | 0.36 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL736092 | 0.89 | POLB (0.39) | KMT2AALDH1A1SMN1; SMN2MEN1NPC1 | |
| SCHEMBL735386 | 0.85 | AKR1C1 (0.61) | AKR1C1KMT2ATET3FBXL19CXXC5 | |
| SCHEMBL4152236 | 0.81 | ALDH1A1 (0.34) | KMT2AALDH1A1SMN1; SMN2MEN1NPC1 | |
| SCHEMBL3134616 | 0.77 | MEN1 (0.38) | AKR1C1KMT2AMEN1HDAC4 | |
| SCHEMBL23248029 | 0.73 | ALDH1A1 (0.39) | KMT2AALDH1A1ALOX15SMN1; SMN2MEN1 | |
| SCHEMBL3219496 | 0.72 | APP (0.50) | AKR1C1KMT2AHSD11B1NPC1RAB9A | |
| SCHEMBL31016196 | 0.72 | AKR1C1 (0.83) | AKR1C1KMT2ATET3FBXL19CXXC5 | |
| SCHEMBL6391 | 0.72 | AKR1C1 (0.83) | AKR1C1KMT2ATET3FBXL19CXXC5 | |
| SCHEMBL1313846 | 0.70 | AKR1C1 (0.42) | AKR1C1HDAC4 | |
| SCHEMBL4322724 | 0.70 | AKR1C1 (0.38) | AKR1C1KMT2AHSD11B1MEN1HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044016-A2 | 4-HETEROARYL-SUBSTITUTED 1-AMINOCYCLOHEXANE-1-AND CYCLOHEXENE-1-DERIVATIVES HAVING EFFECTS ON THE OPIOD RECEPTOR SYSTEM | Grünenthal GmbH (DE) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008009415-A2 | 4-HETEROARYL-SUBSTITUTED 1-AMINOCYCLOHEXANE-1- AND CYCLOHEXENE-1-DERIVATIVES HAVING EFFECTS ON THE OPIOD RECEPTOR SYSTEM | Grünenthal GmbH (DE) | 2008-01-24 | — | — | WO | disclosed |