Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | BRD4 | O60885 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.34 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.34 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.34 |
| ▸ | CD4 | P01730 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4171140 | 0.90 | PTPN11 (0.51) | PTPN11L3MBTL1BRD4ALDH1A1LMNA | |
| SCHEMBL4171120 | 0.82 | PTPN11 (0.75) | PTPN11L3MBTL1BRD4 | |
| SCHEMBL4159580 | 0.81 | PTPN11 (0.56) | PTPN11L3MBTL1BRD4ALDH1A1LMNA | |
| SCHEMBL23247251 | 0.77 | L3MBTL1 (0.58) | PTPN11L3MBTL1BRD4ALDH1A1LMNA | |
| SCHEMBL4169651 | 0.76 | PTPN11 (0.56) | PTPN11L3MBTL1BRD4SMN1; SMN2 | |
| SCHEMBL4163963 | 0.76 | PTPN11 (0.52) | PTPN11L3MBTL1BRD4ALDH1A1LMNA | |
| SCHEMBL1850782 | 0.76 | BRD4 (0.64) | PTPN11L3MBTL1BRD4ALDH1A1LMNA | |
| SCHEMBL4160192 | 0.76 | PTPN11 (0.53) | PTPN11L3MBTL1BRD4ALDH1A1LMNA | |
| SCHEMBL17200871 | 0.76 | KDR (0.51) | PTPN11BRD4MAPTHTR6MEN1 | |
| SCHEMBL23247697 | 0.75 | L3MBTL1 (0.55) | PTPN11L3MBTL1BRD4ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120238588-A1 | 1H-Pyrrolo[2,3-B]Pyridines | GlaxoSmithKline, LLC | 2012-09-20 | — | — | US | disclosed |
| US-20090233955-A1 | 1H-Pyrrolo[2,3-B]Pyridnes | GLAXOSMITHKLINE LLC | 2009-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233955-A1 | 1H-Pyrrolo[2,3-B]Pyridnes | SGK1, SGK2, SGK3 | PTPN11 641/4885L3MBTL1 4480/4885BRD4 939/4885 |
| US-20120238588-A1 | 1H-Pyrrolo[2,3-B]Pyridines | SGK1, SGK2, SGK3 | PTPN11 609/4885L3MBTL1 4474/4885BRD4 767/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.