Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 7/20 | 0.62 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.55 |
| ▸ | CLK2 | P49760 | 1/20 | 0.55 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.55 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | PLAU | P00749 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31738598 | 1.00 | MAOB (0.62) | MAOBDYRK1AMAP4K4CLK2SRPK1 | |
| SCHEMBL5409154 | 0.87 | MAOB (0.59) | MAOBDYRK1AMAP4K4CLK2CLK4 | |
| SCHEMBL1608321 | 0.85 | MAOB (0.63) | MAOBDYRK1AMAP4K4CLK2SRPK1 | |
| SCHEMBL30483273 | 0.84 | CHEK2 (0.60) | — | |
| SCHEMBL2933207 | 0.81 | MAPT (0.68) | MAOBDYRK1AMAP4K4CLK2SRPK1 | |
| SCHEMBL30194367 | 0.81 | MAPT (0.68) | MAOBDYRK1AMAP4K4CLK2SRPK1 | |
| SCHEMBL30483194 | 0.81 | CHEK2 (0.49) | MAOBDYRK1AMAP4K4CLK2SRPK1 | |
| SCHEMBL347171 | 0.81 | MAOB (0.55) | MAOBDYRK1AMAP4K4CLK2SRPK1 | |
| SCHEMBL29643878 | 0.81 | MAOB (0.55) | MAOBDYRK1AMAP4K4CLK2SRPK1 | |
| Hydrochloric Acid SCHEMBL30483265 | 0.80 | CHEK2 (0.48) | MAOBDYRK1AMAP4K4CLK2SRPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230312481-A1 | SUBSTITUTED (PHTHALAZIN-1-YLMETHYL)UREAS, SUBSTITUTED N-(PHTHALAZIN-1-YLMETHYL)AMIDES, AND ANALOGUES THEREOF | ARBUTUS BIOPHARMA CORP (CA) | 2023-10-05 | — | — | US | disclosed |
| US-20230101819-A1 | SMYD Inhibitors | EPIZYME INC (US) | 2023-03-30 | — | — | US | disclosed |
| US-20210198252-A1 | SMYD INHIBITORS | EPIZYME INC (US) | 2021-07-01 | — | — | US | disclosed |
| US-20190322660-A1 | SMYD INHIBITORS | Epizyme, Inc. | 2019-10-24 | — | — | US | disclosed |
| US-10266526-B2 | Substituted 1,2,3-triazoles as SMYD inhibitors for treating cancer | Epizyme, Inc. (US) | 2019-04-23 | — | — | US | disclosed |
| US-20170355695-A1 | SMYD Inhibitors | Epizyme, Inc. (US) | 2017-12-14 | — | — | US | disclosed |
| US-20090192155-A1 | Identification of Compounds Suitable for Treating Ad | MERCK SHARP & DOHME LIMITED (GB) | 2009-07-30 | — | — | US | disclosed |
| EP-1983979-A1 | IDENTIFICATION OF COMPOUNDS SUITABLE FOR TREATING AD | Merck Sharp & Dohme Limited (GB) | 2008-10-29 | — | — | EP | disclosed |
| US-20080004259-A1 | Inhibitors of Checkpoint Kinases | MERCK & CO., INC. | 2008-01-03 | — | — | US | disclosed |
| US-20080004259-A1 | Inhibitors of Checkpoint Kinases | MERCK & CO., INC. | 2008-01-03 | — | — | US | disclosed |
| US-20080004259-A1 | Inhibitors of Checkpoint Kinases | MERCK & CO., INC. | 2008-01-03 | — | — | US | disclosed |
| EP-1851203-A2 | INHIBITORS OF CHECKPOINT KINASES | Merck & Co., Inc. (US) | 2007-11-07 | — | — | EP | disclosed |
| WO-2007088400-A1 | IDENTIFICATION OF COMPOUNDS SUITABLE FOR TREATING AD | MERCK SHARP & DOHME LIMITED (GB) | 2007-08-09 | — | — | WO | disclosed |
| WO-2006086255-A2 | INHIBITORS OF CHECKPOINT KINASES | MERCK & CO., INC. (US) | 2006-08-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10266526-B2 | Substituted 1,2,3-triazoles as SMYD inhibitors for treating cancer | SMYD3, SMYD2, SNRPD3 | MAOB 2335/4885DYRK1A 1735/4885MAP4K4 3393/4885 |
| US-20170355695-A1 | SMYD Inhibitors | SMYD3, SMYD2, SMURF2 | MAOB 1275/4885DYRK1A 2314/4885MAP4K4 3946/4885 |
| US-20210198252-A1 | SMYD INHIBITORS | SMYD3, SMYD2, SMURF2 | MAOB 1325/4885DYRK1A 2341/4885MAP4K4 3941/4885 |
| US-20090192155-A1 | Identification of Compounds Suitable for Treating Ad | PSEN2, MAPT, PSEN1 | MAOB 594/4885DYRK1A 2542/4885MAP4K4 372/4885 |
| US-20190322660-A1 | SMYD INHIBITORS | SMYD2, SMYD3, SMURF2 | MAOB 1372/4885DYRK1A 1947/4885MAP4K4 4034/4885 |
| US-20230312481-A1 | SUBSTITUTED (PHTHALAZIN-1-YLMETHYL)UREAS, SUBSTITUTED N-(PHTHALAZIN-1-YLMETHYL)AMIDES, AND ANALOGUES THEREOF | NSD3, PML, NSD1 | MAOB 4105/4885DYRK1A 2269/4885MAP4K4 2500/4885 |
| US-20230101819-A1 | SMYD Inhibitors | SMYD3, SMYD2, SMURF2 | MAOB 1334/4885DYRK1A 2296/4885MAP4K4 3947/4885 |
| US-20080004259-A1 | Inhibitors of Checkpoint Kinases | CHEK1, CHEK2, BUB1B | MAOB 4558/4885DYRK1A 289/4885MAP4K4 256/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.