Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | PI4KA | P42356 | 1/20 | 0.39 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.39 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
| ▸ | CCR8 | P51685 | 1/20 | 0.36 |
| ▸ | METAP1 | P53582 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3394969 | 0.84 | HSP90AA1 (0.33) | KDM4EGAACYP1A2ALDH1A1TDP1 | |
| SCHEMBL7511419 | 0.82 | ALDH1A1 (0.41) | KDM4ECYP1A2LMNAALDH1A1TDP1 | |
| SCHEMBL3361750 | 0.79 | ALDH1A1 (0.42) | NOS3NOS1NOS2PI4KAPI4K2B | |
| Hydrochloric Acid SCHEMBL1718427 | 0.78 | ALDH1A1 (0.42) | KDM4EGAACYP1A2ALDH1A1TDP1 | |
| SCHEMBL193916 | 0.78 | ALDH1A1 (0.46) | KDM4EGAACYP1A2ALDH1A1TDP1 | |
| SCHEMBL1792016 | 0.78 | ALDH1A1 (0.46) | KDM4EGAACYP1A2ALDH1A1TDP1 | |
| Hydrochloric Acid SCHEMBL250009 | 0.75 | ALDH1A1 (0.43) | KDM4EGAACYP1A2BLMALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL28763213 | 0.75 | ALDH1A1 (0.43) | KDM4EGAACYP1A2ALDH1A1TDP1 | |
| Ammonia Solution, Strong SCHEMBL28873134 | 0.75 | ALDH1A1 (0.43) | KDM4EGAACYP1A2ALDH1A1TDP1 | |
| Water SCHEMBL8817645 | 0.75 | ALDH1A1 (0.43) | KDM4EGAACYP1A2ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104109127-B | Kinase inhibitor and the method for treating related disease | 北京大学深圳研究生院 | 2019-11-05 | — | — | CN | disclosed |
| CN-104109127-B | Kinase inhibitor and the method for treating related disease | 北京大学深圳研究生院 | 2019-11-05 | — | — | CN | disclosed |
| CN-109305944-A | The inhibitor of bruton's tyrosine kinase | 深圳睿熙生物科技有限公司 | 2019-02-05 | — | — | CN | disclosed |
| CN-103073508-B | The method of inhibitors of kinases and treatment relevant disease | PEKING UNIVERSITY SHENZHEN GRADUATE SCHOOL (CN) | 2016-06-01 | — | — | CN | disclosed |
| CN-103073508-B | The method of inhibitors of kinases and treatment relevant disease | PEKING UNIVERSITY SHENZHEN GRADUATE SCHOOL (CN) | 2016-06-01 | — | — | CN | disclosed |
| CN-102066339-A | 2, 6-diamino-pyrimidin-5-yl-carboxamides as SYK or JAK protein kinase inhibitors | PORTOLA PHARM INC | 2011-05-18 | — | — | CN | disclosed |
| US-20090240035-A1 | DNA REPLICATION PROTEINS OF GRAM POSITIVE BACTERIA AND THEIR USE TO SCREEN FOR CHEMICAL INHIBITORS | O'DONNELL MICHAEL E | 2009-09-24 | — | — | US | disclosed |
| US-7557184-B2 | Isolated staphylococcus DNAX subunit and use thereof | THE ROCKEFELLER UNIVERSITY (US) | 2009-07-07 | — | — | US | disclosed |
| US-20090123911-A9 | ISOLATED STAPHYLOCOCCUS DNAX SUBUNIT AND USE THEREOF | O'DONNELL MICHAEL E | 2009-05-14 | — | — | US | disclosed |
| US-20090004675-A1 | Method of Identifying Compounds for Bacterial Growth Modulation | THE ROCKEFELLER UNIVERSITY (US) | 2009-01-01 | — | — | US | disclosed |
| US-7432365-B1 | DNA molecules encoding beta clamp proteins of gram positive bacteria | THE ROCKEFELLER UNIVERSITY | 2008-10-07 | — | — | US | disclosed |
| WO-2006052746-A2 | METHOD OF IDENTIFYING COMPOUNDS FOR BACTERIAL GROWTH MODULATION | THE ROCKEFELLER UNIVERSITY (US) | 2006-05-18 | — | — | WO | disclosed |
| US-20030129633-A1 | DNA replication proteins of Gram positive bacteria and their use to screen for chemical inhibitors | O'DONNELL MICHAEL E (US) | 2003-07-10 | — | — | US | disclosed |
| EP-1056763-A4 | DNA REPLICATION PROTEINS OF GRAM POSITIVE BACTERIA AND THEIR USE TO SCREEN FOR CHEMICAL INHIBITORS | UNIV ROCKEFELLER (US) | 2003-03-26 | — | — | EP | disclosed |
| WO-2001009164-A2 | DNA REPLICATION PROTEINS OF GRAM POSITIVE BACTERIA AND THEIR USE TO SCREEN FOR CHEMICAL INHIBITORS | THE ROCKEFELLER UNIVERSITY (US) | 2001-02-08 | — | — | WO | disclosed |
| EP-1056763-A1 | DNA REPLICATION PROTEINS OF GRAM POSITIVE BACTERIA AND THEIR USE TO SCREEN FOR CHEMICAL INHIBITORS | THE ROCKEFELLER UNIVERSITY (US) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999037661-A9 | DNA REPLICATION PROTEINS OF GRAM POSITIVE BACTERIA AND THEIR USE TO SCREEN FOR CHEMICAL INHIBITORS | UNIV ROCKEFELLER (US) | 1999-12-02 | — | — | WO | disclosed |
| WO-1999037661-A1 | DNA REPLICATION PROTEINS OF GRAM POSITIVE BACTERIA AND THEIR USE TO SCREEN FOR CHEMICAL INHIBITORS | THE ROCKEFELLER UNIVERSITY (US) | 1999-07-29 | — | — | WO | disclosed |