SCHEMBL4155818

SCHEMBL4155818

C[C@@H](O)[C@H]1C(=O)N2C(C(=O)OCc3ccc([N+](=O)[O-])cc3)=C(c3cn4cnc(C(=O)c5cccnc5)c4s3)[C@H](C)[C@H]12

nearest known ligand 0.33

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.33
L3MBTL1 Q9Y468 2/20 0.33
PLCG1 P19174 1/20 0.33
ELANE P08246 3/20 0.32
RAB9A P51151 2/20 0.32
NPSR1 Q6W5P4 1/20 0.32
KMT2A Q03164 2/20 0.32
HTT P42858 1/20 0.32
MEN1 O00255 1/20 0.32
RXFP1 Q9HBX9 1/20 0.31
HTR2A P28223 1/20 0.30
LMNA P02545 1/20 0.30
TDP1 Q9NUW8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7722352 0.93 PLCG1 (0.38) L3MBTL1PLCG1ELANERAB9AHTT
SCHEMBL5233536 0.89 PLCG1 (0.32) PLCG1ELANEHTTHTR2A
SCHEMBL7041829 0.88 PLCG1 (0.35) L3MBTL1PLCG1ELANEHTTHTR2A
SCHEMBL7728957 0.88 PLCG1 (0.37) MAPTL3MBTL1PLCG1ELANEHTT
SCHEMBL7730230 0.88 PLCG1 (0.35) L3MBTL1PLCG1ELANERAB9AHTT
SCHEMBL7728647 0.88 ELANE (0.36) L3MBTL1PLCG1ELANEHTTHTR2A
SCHEMBL7730458 0.88 PLCG1 (0.35) L3MBTL1PLCG1ELANERAB9AHTT
SCHEMBL7722446 0.88 ELANE (0.36) L3MBTL1PLCG1ELANEHTTHTR2A
SCHEMBL7003427 0.88 RAB9A (0.36) L3MBTL1PLCG1ELANERAB9AKMT2A
SCHEMBL7631759 0.87 PLCG1 (0.36) L3MBTL1PLCG1ELANEHTTHTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090082571-A1 Intermediates of 2-substituted carbapenem derivatives and process for production thereof SASAKI TOSHIRO 2009-03-26 US disclosed
EP-1582522-A1 INTERMEDIATE FOR 2-SUBSTITUTED CARBAPENEM DERIVATIVE AND PRODUCTION PROCESS MEIJI SEIKA KAISHA LTD. (JP) 2005-10-05 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090082571-A1 Intermediates of 2-substituted carbapenem derivatives and process for production thereof MGAM, G6PD, COASY MAPT 4112/4885L3MBTL1 3309/4885PLCG1 2811/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.