Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLH | Q9Y253 | 6/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.70 |
| ▸ | POLB | P06746 | 2/20 | 0.70 |
| ▸ | APEX1 | P27695 | 2/20 | 0.70 |
| ▸ | RECQL | P46063 | 2/20 | 0.70 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.70 |
| ▸ | RPS6KA3 | P51812 | 5/20 | 0.60 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.60 |
| ▸ | CA12 | O43570 | 2/20 | 0.60 |
| ▸ | CA2 | P00918 | 2/20 | 0.60 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.60 |
| ▸ | ACHE | P22303 | 2/20 | 0.60 |
| ▸ | CA7 | P43166 | 2/20 | 0.60 |
| ▸ | SLCO2B1 | O94956 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4159721 | 0.92 | ABCB1 (0.71) | POLHCYP3A4CYP2D6KDM4EPOLB | |
| SCHEMBL4157811 | 0.91 | POLH (0.67) | POLHCYP3A4CYP2D6KDM4EPOLB | |
| SCHEMBL4170634 | 0.91 | POLH (0.74) | POLHCYP3A4CYP2D6KDM4EPOLB | |
| SCHEMBL4170658 | 0.88 | KDM4E (0.61) | POLHCYP3A4CYP2D6KDM4EPOLB | |
| SCHEMBL4164863 | 0.88 | POLH (0.64) | POLHCYP3A4CYP2D6KDM4EPOLB | |
| SCHEMBL4156059 | 0.87 | POLH (0.62) | POLHCYP3A4CYP2D6KDM4EPOLB | |
| SCHEMBL4157686 | 0.87 | POLH (0.62) | POLHCYP3A4CYP2D6KDM4EPOLB | |
| SCHEMBL4167868 | 0.87 | POLH (0.62) | POLHCYP3A4CYP2D6KDM4EPOLB | |
| SCHEMBL4162160 | 0.87 | POLH (0.62) | POLHCYP3A4CYP2D6KDM4EPOLB | |
| SCHEMBL4155950 | 0.87 | POLH (0.62) | POLHCYP3A4CYP2D6KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090130051-A1 | Flavonoid Compounds and Uses Thereof | HOWARD FLOREY INSTITUTE OF EXPERIMENTAL PHYSIOLOGY AND MEDICINE (AU) | 2009-05-21 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090130051-A1 | Flavonoid Compounds and Uses Thereof | CAT, NQO1, GPX4 | POLH 3392/4885CYP3A4 518/4885CYP2D6 297/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.