Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 19/20 | 1.00 |
| ▸ | CASP7 | P55210 | 16/20 | 1.00 |
| ▸ | CASP1 | P29466 | 6/20 | 0.89 |
| ▸ | CASP6 | P55212 | 4/20 | 0.89 |
| ▸ | CASP9 | P55211 | 3/20 | 0.89 |
| ▸ | CASP2 | P42575 | 3/20 | 0.89 |
| ▸ | CASP4 | P49662 | 2/20 | 0.89 |
| ▸ | CASP8 | Q14790 | 2/20 | 0.89 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4143950 | 1.00 | CASP3 (1.00) | CASP3CASP7CASP1CASP6CASP9 | |
| SCHEMBL2263591 | 0.94 | CASP3 (1.00) | CASP3CASP7CASP1CASP6CASP9 | |
| SCHEMBL7736082 | 0.94 | CASP3 (0.96) | CASP3CASP7CASP1CASP6CASP9 | |
| SCHEMBL4094113 | 0.94 | CASP3 (1.00) | CASP3CASP7CASP1CASP6CASP9 | |
| SCHEMBL6535137 | 0.85 | CASP3 (0.84) | CASP3CASP7CASP1CASP6CASP9 | |
| SCHEMBL6535139 | 0.85 | CASP3 (0.84) | CASP3CASP7CASP1CASP6CASP9 | |
| SCHEMBL6535497 | 0.84 | CASP3 (0.82) | CASP3CASP7CASP1CASP6CASP9 | |
| SCHEMBL6535499 | 0.84 | CASP3 (0.82) | CASP3CASP7CASP1CASP6CASP9 | |
| SCHEMBL6535719 | 0.84 | CASP3 (0.82) | CASP3CASP7CASP1CASP6CASP9 | |
| SCHEMBL6535718 | 0.84 | CASP3 (0.82) | CASP3CASP7CASP1CASP6CASP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8329686-B2 | Isatin analogues and uses therefor | WASHINGTON UNIVERSITY (US) | 2012-12-11 | — | — | US | disclosed |
| US-20090068105-A1 | ISATIN ANALOGUES AND USES THEREFOR | WASHINGTON UNIVERSITY IN ST. LOUIS | 2009-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090068105-A1 | ISATIN ANALOGUES AND USES THEREFOR | CASP7, CASP3, HASPIN | CASP3 2/4885CASP7 1/4885CASP1 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.