Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.65 |
| ▸ | CLK1 | P49759 | 1/20 | 0.65 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.65 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.65 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.65 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.65 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.65 |
| ▸ | PIM1 | P11309 | 7/20 | 0.65 |
| ▸ | PIM2 | Q9P1W9 | 7/20 | 0.65 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.65 |
| ▸ | AKR1B1 | P15121 | 5/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7519991 | 0.85 | CSNK2A2 (0.65) | CSNK2A2CLK1CSNK2BCSNK2A1DYRK1A | |
| SCHEMBL5673273 | 0.83 | TDP1 (0.66) | CSNK2A2CLK1CSNK2BCSNK2A1DYRK1A | |
| SCHEMBL6860373 | 0.83 | PIM1 (0.66) | CSNK2A2CLK1CSNK2BCSNK2A1DYRK1A | |
| SCHEMBL6860827 | 0.83 | PIM1 (0.66) | CSNK2A2CLK1CSNK2BCSNK2A1DYRK1A | |
| SCHEMBL8616061 | 0.83 | PIM1 (0.66) | CSNK2A2CLK1CSNK2BCSNK2A1DYRK1A | |
| SCHEMBL9326985 | 0.83 | CSNK2A2 (0.62) | CSNK2A2CLK1CSNK2BCSNK2A1DYRK1A | |
| SCHEMBL5674905 | 0.82 | TDP1 (0.63) | CSNK2A2CLK1CSNK2BCSNK2A1DYRK1A | |
| SCHEMBL30093816 | 0.81 | PIM1 (0.56) | CSNK2A2CLK1CSNK2BCSNK2A1DYRK1A | |
| SCHEMBL7463867 | 0.81 | PIM1 (0.68) | CSNK2A2CLK1CSNK2BCSNK2A1DYRK1A | |
| SCHEMBL7464574 | 0.80 | PIM1 (0.68) | CSNK2A2CLK1CSNK2BCSNK2A1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1252065-A | Process for preparing substituted thiazolidinedione | SMITHKLINE BEECHAM PLC (GB) | 2000-05-03 | — | — | CN | claimed |
| CN-118108785-A | 5 Alpha, 8 alpha-peroxy ergosterol-3-thiazolidinedione derivative, and preparation method and application thereof | 齐齐哈尔医学院 | 2024-05-31 | — | — | CN | disclosed |
| US-10689374-B1 | Pyrimidine-thiazolidinone derivatives | UNITED ARAB EMIRATES UNIVERSITY (AE) | 2020-06-23 | — | — | US | disclosed |
| WO-2019016826-A1 | NOVEL 5-[4-(2-BIPHENYL-4-YL-2-OXO-ETHOXY)-BENZYLIDENE]-THIAZOLIDINE-2,4-DIONES, THEIR SYNTHESIS AND USES THEREOF | GURU GHASIDAS VISHWAVIDYALAYA (A CENTRAL UNIVERSITY) (IN) | 2019-01-24 | — | — | WO | disclosed |
| CN-101973957-B | 5-benzylidene-2,4-thiazolidinedione derivatives and preparation method and application thereof | UNIV SICHUAN | 2012-11-21 | — | — | CN | disclosed |
| CN-101973957-B | 5-benzylidene-2,4-thiazolidinedione derivatives and preparation method and application thereof | UNIV SICHUAN | 2012-11-21 | — | — | CN | disclosed |
| CN-101361737-B | Use of 4-tetrahydrothiazole dione derivates | UNIV SICHUAN | 2011-08-03 | — | — | CN | disclosed |
| CN-101361737-B | Use of 4-tetrahydrothiazole dione derivates | UNIV SICHUAN | 2011-08-03 | — | — | CN | disclosed |
| CN-101973957-A | 5-benzylidene-2,4-thiazolidinedione derivatives and preparation method and application thereof | UNIV SICHUAN | 2011-02-16 | — | — | CN | disclosed |
| CN-101973957-A | 5-benzylidene-2,4-thiazolidinedione derivatives and preparation method and application thereof | UNIV SICHUAN | 2011-02-16 | — | — | CN | disclosed |
| EP-0612729-B1 | Pyridine derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-04-23 | — | — | EP | disclosed |
| US-5561147-A | ANTIINFLAMMATORY AGENT, ANTIPYRETIC, ANALGESICS, ANTIALLERGENS, IMMUNOSUPPRESSANTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-10-01 | — | — | US | disclosed |
| US-5478850-A | Treating hyperglycemia, hyperlipidemia, hypertension | BEECHAM GROUP PLC (GB) | 1995-12-26 | — | — | US | disclosed |
| US-5457106-A | Antiinflammatory agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-10-10 | — | — | US | disclosed |
| US-5389658-A | Administering as antipyretic, antiinflammatory, analgesic, antiallergic, or immunosupressive agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-02-14 | — | — | US | disclosed |
| EP-0612729-A2 | Pyridine derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1994-08-31 | — | — | EP | disclosed |
| US-5246948-A | Antiinflammatory, antipyretic, analgesic, antiallergic, immunosupressing or immunomodulating activity | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-09-21 | — | — | US | disclosed |
| EP-0555249-A1 | THIAZOLIDINEDIONE DERIVATIVES | BEECHAM GROUP plc (GB) | 1993-08-18 | — | — | EP | disclosed |
| EP-0522606-A2 | Pyridine derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-01-13 | — | — | EP | disclosed |
| WO-1992007839-A1 | THIAZOLIDINEDIONE DERIVATIVES | BEECHAM GROUP PLC (GB) | 1992-05-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10689374-B1 | Pyrimidine-thiazolidinone derivatives | TYMS, DPYD, TK2 | CSNK2A2 1435/4885CLK1 2870/4885CSNK2B 1866/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.