Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 8/20 | 0.68 |
| ▸ | PIM2 | Q9P1W9 | 8/20 | 0.68 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.55 |
| ▸ | CLK1 | P49759 | 1/20 | 0.55 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.55 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.55 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.55 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.55 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.55 |
| ▸ | NAT1 | P18440 | 1/20 | 0.54 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | CISD1 | Q9NZ45 | 3/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TTR | P02766 | 1/20 | 0.43 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7463867 | 0.83 | PIM1 (0.68) | PIM1PIM2CSNK2A2CLK1CSNK2B | |
| SCHEMBL2539680 | 0.81 | PIM1 (1.00) | PIM1PIM2NAT1AKR1B1GSK3B | |
| SCHEMBL2539679 | 0.81 | PIM1 (1.00) | PIM1PIM2NAT1AKR1B1GSK3B | |
| SCHEMBL2539676 | 0.81 | PIM1 (1.00) | PIM1PIM2NAT1AKR1B1GSK3B | |
| SCHEMBL7465312 | 0.81 | CSNK2A2 (0.51) | PIM1PIM2CSNK2A2CLK1CSNK2B | |
| SCHEMBL7459912 | 0.81 | GSK3B (0.71) | PIM1PIM2CSNK2A2CLK1CSNK2B | |
| SCHEMBL7466029 | 0.81 | CSNK2A1 (0.71) | PIM1PIM2CSNK2A2CLK1CSNK2B | |
| SCHEMBL4156417 | 0.80 | CSNK2A2 (0.65) | PIM1PIM2CSNK2A2CLK1CSNK2B | |
| SCHEMBL3787295 | 0.77 | IGF1R (0.71) | CSNK2A2CLK1CSNK2BCSNK2A1DYRK1A | |
| SCHEMBL7466320 | 0.75 | PIM1 (0.73) | PIM1PIM2CSNK2A2CLK1CSNK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214305-A1 | BENZYLIDENE-THIAZOLIDINEDIONES AND ANALOGUES AND THEIR USE IN THE TREATMENT OF INFLAMMATION | Maxia Pharmaceuticals, Inc. (US) | 2002-06-19 | — | — | EP | claimed |
| WO-2001016123-A1 | BENZYLIDENE-THIAZOLIDINEDIONES AND ANALOGUES AND THEIR USE IN THE TREATMENT OF INFLAMMATION | MAXIA PHARMACEUTICALS, INC. (US) | 2001-03-08 | — | — | WO | claimed |