Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 3/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | SNCA | P37840 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | PTGDR | Q13258 | 3/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14651868 | 0.75 | HDAC1 (0.74) | HDAC1KMT2AMAPTMEN1NPC1 | |
| SCHEMBL3393585 | 0.75 | CSNK2A2 (0.48) | NAMPTHDAC1BCHEACHEKMT2A | |
| SCHEMBL4148108 | 0.74 | FYN (0.41) | MAPTSMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL20284424 | 0.74 | RAB9A (0.71) | NAMPTBCHEACHEKMT2APOLB | |
| SCHEMBL3249345 | 0.73 | SMN1; SMN2 (0.62) | HDAC1MAPTSMN1; SMN2ALDH1A1PTGDR | |
| SCHEMBL4139805 | 0.73 | FYN (0.56) | MAPTSMN1; SMN2ALDH1A1TP53ALOX15 | |
| SCHEMBL4139796 | 0.73 | CYP1A2 (0.47) | MAPTSMN1; SMN2ALDH1A1PTGDRCYP2C19 | |
| SCHEMBL20379201 | 0.73 | NAMPT (1.00) | NAMPTHDAC1 | |
| SCHEMBL3271513 | 0.73 | RAB9A (0.77) | NAMPTKMT2APOLBMEN1SMN1; SMN2 | |
| SCHEMBL3270932 | 0.73 | RAB9A (0.77) | NAMPTBCHEACHEKMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090163515-A1 | Compounds Which Bind to the Active Site of Protein Kinase Enzymes | BIOFOCUS DISCOVERY LTD. | 2009-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163515-A1 | Compounds Which Bind to the Active Site of Protein Kinase Enzymes | ROCK1, ROCK2, CIT | NAMPT 2610/4885HDAC1 2655/4885SNCA 1397/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.