Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.35 |
| ▸ | CDK8 | P49336 | 4/20 | 0.35 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.35 |
| ▸ | CAMK2A | Q9UQM7 | 2/20 | 0.35 |
| ▸ | LTK | P29376 | 2/20 | 0.35 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.35 |
| ▸ | MST1R | Q04912 | 2/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | PAK4 | O96013 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8987328 | 0.75 | PARP1 (0.48) | PARP1CCNE1CDK2ALDH1A1KDM4E | |
| SCHEMBL3485241 | 0.74 | PARP1 (0.47) | PARP1CCNE1CDK2ALDH1A1KDM4E | |
| SCHEMBL4915150 | 0.65 | MAPT (0.42) | PARP1ALDH1A1MAP2K1NTRK1KIT | |
| SCHEMBL8090609 | 0.63 | CCNE1 (0.47) | PARP1CCNE1CDK2ALDH1A1LRRK2 | |
| SCHEMBL7392387 | 0.63 | KDM4E (0.46) | ALDH1A1KDM4ELMNACDK8CLK4 | |
| SCHEMBL10507983 | 0.61 | ALDH1A1 (0.44) | ALDH1A1KDM4ECYP1A2L3MBTL1MAPT | |
| SCHEMBL4208272 | 0.61 | PARP1 (1.00) | PARP1CDK2ALDH1A1KDM4ECDK8 | |
| SCHEMBL6034222 | 0.60 | CHUK (0.51) | ALDH1A1KDM4ELMNALRRK2CYP1A2 | |
| SCHEMBL16652420 | 0.60 | CCNE1 (0.47) | PARP1CCNE1CDK2ALDH1A1KDM4E | |
| SCHEMBL3485414 | 0.60 | ALDH1A1 (1.00) | PARP1ALDH1A1KDM4ELMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2647382-A1 | Compositions and methods for treating epithelial and retinal tissue diseases | Inspire Pharmaceuticals, Inc. (US) | 2013-10-09 | — | — | EP | disclosed |
| US-7612047-B2 | Degradation-resistant mononucleoside phosphate compounds | INSPIRE PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |
| US-20090076256-A1 | DEGRADATION-RESISTANT MONONUCLEOSIDE PHOSPHATE COMPOUNDS | DOUGLASS III JAMES G | 2009-03-19 | — | — | US | disclosed |
| US-7115585-B2 | Compositions for treating epithelial and retinal tissue diseases | INSPIRE PHARMACEUTICALS, INC. (US) | 2006-10-03 | — | — | US | disclosed |
| EP-1545555-A2 | COMPOSITIONS AND METHODS FOR TREATING EPITHELIAL AND RETINAL TISSUE DISEASES | Inspire Pharmaceuticals, Inc. (US) | 2005-06-29 | — | — | EP | disclosed |
| WO-2003072067-A2 | COMPOSITIONS AND METHODS FOR TREATING EPITHELIAL AND RETINAL TISSUE DISEASES | INSPIRE PHARMACEUTICALS, INC. (US) | 2003-09-04 | — | — | WO | disclosed |
| US-20030008834-A1 | Compsoitions and methods for treating epithelia and retinal tissue diseases | INSPIRE PHARMACEUTICALS, INC. | 2003-01-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030008834-A1 | Compsoitions and methods for treating epithelia and retinal tissue diseases | ENPP1, PNKP, ENTPD5 | PARP1 69/4885CCNE1 4400/4885CDK2 3828/4885 |
| US-20090076256-A1 | DEGRADATION-RESISTANT MONONUCLEOSIDE PHOSPHATE COMPOUNDS | PNKP, ENTPD5, ENPP1 | PARP1 68/4885CCNE1 4136/4885CDK2 2579/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.