Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.34 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.33 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4154022 | 0.87 | KDM4E (0.42) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL3003159 | 0.83 | KDM4E (0.46) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL3004233 | 0.82 | KDM4E (0.42) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL4141571 | 0.82 | KDM4E (0.41) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL27813249 | 0.82 | METTL3 (0.44) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL2990529 | 0.81 | METTL3 (0.50) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL3002686 | 0.79 | PTPN1 (0.40) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL4144523 | 0.79 | ALDH1A1 (0.48) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL3008256 | 0.79 | PTPN1 (0.39) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL27833174 | 0.79 | PTPN1 (0.41) | KDM4EALDH1A1HPGDHSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090170791-A1 | MACROLONES | GLAXO SMITH KLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O A CORPORATION | 2009-07-02 | — | — | US | disclosed |
| EP-1945652-A1 | MACROLONES | GLAXO GROUP LIMITED (GB) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007054296-A1 | MACROLONES | GLAXO GROUP LIMITED (GB) | 2007-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090170791-A1 | MACROLONES | CYP51A1, MRPL21, LSS | KDM4E 4180/4885ALDH1A1 3645/4885HPGD 2439/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.