Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLH | Q9Y253 | 8/20 | 0.71 |
| ▸ | SRC | P12931 | 4/20 | 0.64 |
| ▸ | TOP2A | P11388 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | MMP1 | P03956 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 2/20 | 0.64 |
| ▸ | GAA | P10253 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | APEX1 | P27695 | 2/20 | 0.64 |
| ▸ | RECQL | P46063 | 2/20 | 0.64 |
| ▸ | BLM | P54132 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.62 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.55 |
| ▸ | BCL9 | O00512 | 1/20 | 0.55 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.55 |
| ▸ | MGAM | O43451 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL925099 | 1.00 | POLH (0.71) | POLHSRCTOP2AKDM4EMEN1 | |
| SCHEMBL4163382 | 1.00 | POLH (0.71) | POLHSRCTOP2AKDM4EMEN1 | |
| SCHEMBL4153380 | 1.00 | POLH (0.71) | POLHSRCTOP2AKDM4EMEN1 | |
| SCHEMBL31236656 | 1.00 | POLH (0.71) | POLHSRCTOP2AKDM4EMEN1 | |
| SCHEMBL4175309 | 1.00 | POLH (0.71) | POLHSRCTOP2AKDM4EMEN1 | |
| SCHEMBL4170099 | 1.00 | POLH (0.71) | POLHSRCTOP2AKDM4EMEN1 | |
| SCHEMBL4170035 | 1.00 | POLH (0.71) | POLHSRCTOP2AKDM4EMEN1 | |
| SCHEMBL4172289 | 1.00 | POLH (0.71) | POLHSRCTOP2AKDM4EMEN1 | |
| SCHEMBL4170652 | 1.00 | POLH (0.71) | POLHSRCTOP2AKDM4EMEN1 | |
| SCHEMBL4169970 | 0.99 | POLH (0.73) | POLHSRCTOP2AKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090130051-A1 | Flavonoid Compounds and Uses Thereof | HOWARD FLOREY INSTITUTE OF EXPERIMENTAL PHYSIOLOGY AND MEDICINE (AU) | 2009-05-21 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090130051-A1 | Flavonoid Compounds and Uses Thereof | CAT, NQO1, GPX4 | POLH 3392/4885SRC 2708/4885TOP2A 4491/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.