Sugi Predict

Sugi Predict / Compounds / Propionic Acid

Propionic Acid

Propionic Acid

SCHEMBL4159513

CCC(=O)O.O=c1[nH]c2ccc(-c3cc[nH]n3)cc2c2cc[nH]c12

nearest known ligand 0.33

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GABRA1 P14867 2/20 0.33
▸ GABRG2 P18507 2/20 0.33
▸ GABRB3 P28472 2/20 0.33
▸ GABRA5 P31644 2/20 0.33
▸ GABRA3 P34903 2/20 0.33
▸ GABRA2 P47869 2/20 0.33
▸ GABRA6 Q16445 2/20 0.33
▸ PIM1 P11309 2/20 0.33
▸ ALDH1A1 P00352 5/20 0.33
▸ HPGD P15428 3/20 0.33
▸ CSF1R P07333 2/20 0.33
▸ GSK3A P49840 1/20 0.33
▸ GSK3B P49841 1/20 0.33
▸ PRKAG1 P54619 1/20 0.33
▸ PRKAA1 Q13131 1/20 0.33
▸ PRKAB1 Q9Y478 1/20 0.33
▸ GRIK1 P39086 1/20 0.33
▸ GRIK2 Q13002 1/20 0.33
▸ GRIK3 Q13003 1/20 0.33
▸ LIMK1 P53667 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Propionic Acid SCHEMBL4153840 0.85 PIM1 (0.44) GABRA1GABRG2GABRB3GABRA5GABRA3
Propionic Acid SCHEMBL4167721 0.83 PRKAG1 (0.46) ALDH1A1HPGDGSK3AGSK3BPRKAG1
Propionic Acid SCHEMBL4162600 0.83 PARP1 (0.38) GABRA1GABRG2GABRB3GABRA5GABRA3
Propionic Acid SCHEMBL4159413 0.83 ADORA2A (0.36) PIM1ALDH1A1KDM4EKMT2A
Propionic Acid SCHEMBL4160151 0.82 PTGS2 (0.48) GSK3AGSK3B
Propionic Acid SCHEMBL4155444 0.81 PARP1 (0.43) PIM1ALDH1A1GSK3BMAPTKDM4E
Propionic Acid SCHEMBL4153298 0.81 PARP1 (0.45) PIM1ALDH1A1HPGDGSK3BMAPT
Propionic Acid SCHEMBL4157712 0.80 CDK2 (0.41) PIM1GSK3BPIM3
Propionic Acid SCHEMBL4162124 0.80 RIOK2 (0.50) PRKAG1PRKAA1PRKAB1
Propionic Acid SCHEMBL4155220 0.80 FASN (0.41) PIM1CSF1RGSK3BGRIK1GRIK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8426437-B2 Pyrroloquinoline derivatives and their use as protein kinases inhibitors PIERRE FABRE MEDICAMENT (FR) 2013-04-23 — — US claimed
US-20090042876-A1 Pyrroloquinoline Derivatives And Their Use As Protein Kinases Inhibitors PIERRE FABRE MEDICAMENT (FR) 2009-02-12 — — US claimed
US-8426437-B2 Pyrroloquinoline derivatives and their use as protein kinases inhibitors PIERRE FABRE MEDICAMENT (FR) 2013-04-23 — — US disclosed
US-20090042876-A1 Pyrroloquinoline Derivatives And Their Use As Protein Kinases Inhibitors PIERRE FABRE MEDICAMENT (FR) 2009-02-12 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090042876-A1 Pyrroloquinoline Derivatives And Their Use As Protein Kinases Inhibitors MAP3K1, MAP3K2, MAP3K7 GABRA1 3395/4885GABRG2 2327/4885GABRB3 2308/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.