Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.66 |
| ▸ | PNP | P00491 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.64 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.64 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.54 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4159592 | 1.00 | ADORA3 (0.66) | ADORA3PNPLMNATP53HTT | |
| SCHEMBL5982340 | 0.86 | PNP (0.72) | ADORA3PNPLMNATP53HTT | |
| SCHEMBL7742867 | 0.86 | PNP (0.72) | ADORA3PNPLMNATP53HTT | |
| SCHEMBL5982348 | 0.86 | PNP (0.72) | ADORA3PNPLMNATP53HTT | |
| SCHEMBL7742863 | 0.86 | PNP (0.72) | ADORA3PNPLMNATP53HTT | |
| SCHEMBL28769810 | 0.83 | ADORA3 (0.93) | ADORA3P2RX3ADORA2ASLC29A1 | |
| SCHEMBL7111379 | 0.81 | PNP (0.76) | PNPLMNATP53HTTPDE4D | |
| SCHEMBL11949491 | 0.81 | PNP (0.76) | PNPLMNATP53HTTPDE4D | |
| SCHEMBL15459906 | 0.81 | PNP (0.76) | PNPLMNATP53HTTPDE4D | |
| SCHEMBL6848324 | 0.81 | PNP (0.76) | PNPLMNATP53HTTPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090048203-A1 | SUBSTITUTED ADENINES AND THE USES THEREOF | ASTRAZENECA AB (SE) | 2009-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048203-A1 | SUBSTITUTED ADENINES AND THE USES THEREOF | HPRT1, APRT, NUDT1 | ADORA3 29/4885PNP 7/4885LMNA 2243/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.