SCHEMBL4159752

SCHEMBL4159752

SCCCNc1ccccc1

nearest known ligand 0.73

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.73
MAPT P10636 1/20 0.73
L3MBTL1 Q9Y468 1/20 0.50
HDAC3 O15379 13/20 0.46
HDAC1 Q13547 13/20 0.46
HDAC2 Q92769 13/20 0.46
HDAC4 P56524 12/20 0.46
HDAC7 Q8WUI4 12/20 0.46
HDAC10 Q969S8 12/20 0.46
HDAC11 Q96DB2 12/20 0.46
HDAC8 Q9BY41 12/20 0.46
HDAC6 Q9UBN7 12/20 0.46
HDAC9 Q9UKV0 12/20 0.46
HDAC5 Q9UQL6 12/20 0.46
IDO1 P14902 1/20 0.40
DPP7 Q9UHL4 1/20 0.40
NCOR2 Q9Y618 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4164952 0.93 ALDH1A1 (0.70) ALDH1A1MAPTL3MBTL1HDAC3HDAC1
SCHEMBL15902716 0.91 ALDH1A1 (0.67) ALDH1A1MAPTL3MBTL1HDAC3HDAC1
SCHEMBL9579878 0.86 ALDH1A1 (0.59) ALDH1A1MAPTL3MBTL1HDAC3HDAC1
SCHEMBL790635 0.85 ALDH1A1 (0.64) ALDH1A1MAPTL3MBTL1HDAC3HDAC1
SCHEMBL4970157 0.85 ALDH1A1 (0.89) ALDH1A1MAPTL3MBTL1HDAC3HDAC1
SCHEMBL2065279 0.85 ALDH1A1 (1.00) ALDH1A1MAPTL3MBTL1HDAC3HDAC1
SCHEMBL9579770 0.84 ALDH1A1 (0.57) ALDH1A1MAPTL3MBTL1HDAC3HDAC1
SCHEMBL14968385 0.82 ALDH1A1 (0.84) ALDH1A1MAPTL3MBTL1HDAC3HDAC1
SCHEMBL11759173 0.82 ALDH1A1 (0.84) ALDH1A1MAPTL3MBTL1HDAC3HDAC1
Hydrochloric Acid SCHEMBL3634998 0.82 ALDH1A1 (0.94) ALDH1A1MAPTL3MBTL1HDAC3HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3653104-A1 FLEXIBLE TUBE FOR ENDOSCOPE, ENDOSCOPE TYPE MEDICAL DEVICE, AND METHODS FOR PRODUCING THESE FUJIFILM Corporation (JP) 2020-05-20 EP disclosed
US-8022059-B2 Indazole acrylic acid amide compound MITSUBISHI TANABE PHARMA CORPORATION (JP) 2011-09-20 US disclosed
US-20100256108-A1 INDAZOLE ACRYLIC ACID AMIDE COMPOUND MITSUBISHI TANABE PHARMA CORPORATION (JP) 2010-10-07 US disclosed
US-20090030099-A1 FOAM COMPOSITION AND FOAM THE YOKOHAMA RUBBER CO., LTD. (JP) 2009-01-29 US disclosed
EP-1724318-A1 METHOD FOR ADHESIVE-BONDING VULCANIZED RUBBER COMPOSITIONS BY THE USE OF THERMOPLASTIC ELASTOMER COMPOSITIONS THE YOKOHAMA RUBBER CO., LTD. (JP) 2006-11-22 EP disclosed
CN-1842578-A Method for adhesive-bonding vulcanized rubber compositions by the use of thermoplastic elastomer compositions YOKOHAMA RUBBER CO LTD (JP) 2006-10-04 CN disclosed
US-20060213605-A1 Method for adhesive-bonding vulcanized rubber compositions by the use of thermoplastic elastomer compositions YOKOHAMA RUBBER CO., LTD., THE (JP) 2006-09-28 US disclosed
US-20060199917-A1 thermoplastic elastomer exhibiting high recyclability and oil resistance as well as excellent mechanical strength, and in particular, excellent resistance to compression set is provided. The thermoplastic resin with epoxy, hydroxy or nitrogen groups in backbone YOKOHAMA RUBBER CO., LTD., THE (JP) 2006-09-07 US disclosed
EP-1695987-A1 Thermoplastic elastomer composition THE YOKOHAMA RUBBER CO., LTD. (JP) 2006-08-30 EP disclosed
US-20060189755-A1 Thermoplastic elastomer composition THE YOKOHAMA RUBBER CO., LTD. 2006-08-24 US disclosed
EP-1079829-B1 USE OF BENZOFUROXAN DERIVATIVES IN TREATING ANGINA PECTORIS TORRENT PHARMACEUTICALS LTD (IN) 2003-07-23 EP disclosed
EP-0164987-A2 7-Oxabicycloheptane substituted prostaglandin analogs E.R. Squibb & Sons, Inc. (US) 1985-12-18 EP disclosed
US-4555523-A 7-Oxabicycloheptane substituted thio prostaglandin analogs and their use in the treatment of thrombolytic disease E. R. SQUIBB & SONS, INC. (US) 1985-11-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100256108-A1 INDAZOLE ACRYLIC ACID AMIDE COMPOUND KCNH2, KCNH3, KCNJ11 ALDH1A1 711/4885MAPT 4800/4885L3MBTL1 2702/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.