SCHEMBL4160309

SCHEMBL4160309

CCCCc1ccc(-c2cccc(C(=O)O)c2O)cc1

nearest known ligand 0.59

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
HNF4A P41235 1/20 0.59
AKR1C2 P52895 1/20 0.56
AKR1C1 Q04828 1/20 0.56
BRS3 P32247 2/20 0.56
RARB P10826 6/20 0.55
LTB4R2 Q9NPC1 5/20 0.54
AGTR1 P30556 2/20 0.50
AGTR2 P50052 2/20 0.50
DHODH Q02127 1/20 0.50
RARA P10276 1/20 0.49
RARG P13631 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL543491 0.94 RARB (0.57) HNF4ARARBRARARARG
SCHEMBL3906504 0.87 BRS3 (0.70) BRS3LTB4R2AGTR1AGTR2DHODH
SCHEMBL5042327 0.86 HNF4A (0.56) HNF4AAKR1C2AKR1C1BRS3LTB4R2
SCHEMBL20504218 0.86 BRS3 (0.56) AKR1C2AKR1C1BRS3RARBLTB4R2
SCHEMBL10536375 0.82 RARB (0.59) BRS3RARBLTB4R2RARARARG
SCHEMBL28435222 0.82 BRS3 (0.61) BRS3RARBLTB4R2AGTR1AGTR2
SCHEMBL10341051 0.81 LTB4R2 (0.65) BRS3RARBLTB4R2RARARARG
SCHEMBL4192326 0.81 LTB4R2 (0.65) BRS3RARBLTB4R2RARARARG
SCHEMBL9665184 0.81 RARB (0.57) RARBLTB4R2RARARARG
SCHEMBL29898487 0.80 RARB (0.63) AKR1C2AKR1C1BRS3RARBDHODH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8673096-B2 Method of fabricating pneumatic tire TOYO TIRE & RUBBER CO., LTD. (JP) 2014-03-18 US disclosed
US-20090032174-A1 METHOD OF FABRICATING PNEUMATIC TIRE TOYO TIRE & RUBBER CO., LTD. (JP) 2009-02-05 US disclosed
EP-0537223-A1 NEW 6-ARYL-6H-DIBENZO-[c,e][1,2]-OXAPHOSPHORINES, A METHOD FOR PREPARING THEM, AND THEIR USE FOR THE STABILIZATION OF PLASTICS, IN PARTICULAR POLYOLEFIN MOULDING MATERIALS. HOECHST AG (DE) 1993-04-21 EP disclosed
WO-1992000306-A1 NEW 6-ARYL-6H-DIBENZO-[c,e][1,2]-OXAPHOSPHORINES, A METHOD FOR PREPARING THEM, AND THEIR USE FOR THE STABILIZATION OF PLASTICS, IN PARTICULAR POLYOLEFIN MOULDING MATERIALS HOECHST AKTIENGESELLSHAFT (DE) 1992-01-09 WO disclosed