Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 6/20 | 0.43 |
| ▸ | FAAH | O00519 | 4/20 | 0.42 |
| ▸ | CES2 | O00748 | 2/20 | 0.42 |
| ▸ | PLA2G6 | O60733 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA9 | Q16790 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4165139 | 0.81 | HDAC1 (0.41) | CES1FAAHCES2PLA2G6HDAC1 | |
| SCHEMBL4160861 | 0.79 | CES1 (0.43) | CES1FAAHCES2PLA2G6HDAC1 | |
| SCHEMBL4164026 | 0.76 | ALDH1A1 (0.54) | CA1 | |
| SCHEMBL4166891 | 0.76 | CES1 (0.52) | CES1HDAC1HDAC2 | |
| Trifluoroacetic Acid SCHEMBL4304780 | 0.74 | CES1 (0.50) | CES1HDAC1HDAC2 | |
| SCHEMBL4606371 | 0.71 | HDAC1 (0.38) | CES1FAAHHDAC1HDAC2 | |
| Trifluoroacetic Acid SCHEMBL4160622 | 0.71 | PADI4 (0.39) | CES1HDAC1HDAC2 | |
| SCHEMBL4171679 | 0.70 | HSD17B10 (0.40) | CES1FAAHHDAC1HDAC2 | |
| SCHEMBL4165142 | 0.70 | CES1 (0.37) | CES1FAAHCES2PLA2G6 | |
| SCHEMBL4166897 | 0.70 | PADI4 (0.41) | CES1FAAHCES2PLA2G6HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090054448-A1 | Amino Acid Derivatives as Histone Deacetylase (HDAC) Inhibitors | JONES PHILIP | 2009-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054448-A1 | Amino Acid Derivatives as Histone Deacetylase (HDAC) Inhibitors | HDAC5, HDAC1, HDAC11 | CES1 1925/4885FAAH 886/4885CES2 3176/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.