Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 2/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.46 |
| ▸ | NPY1R | P25929 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 6/20 | 0.41 |
| ▸ | PADI1 | Q9ULC6 | 3/20 | 0.41 |
| ▸ | PADI4 | Q9UM07 | 3/20 | 0.41 |
| ▸ | PADI2 | Q9Y2J8 | 2/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.40 |
| ▸ | PTPRA | P18433 | 1/20 | 0.40 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | PADI3 | Q9ULW8 | 2/20 | 0.40 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.39 |
| ▸ | CHRNG | P07510 | 1/20 | 0.39 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.39 |
| ▸ | CHRND | Q07001 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4304780 | 0.98 | CES1 (0.50) | CES1HDAC1HDAC2PTPN1NPY1R | |
| Trifluoroacetic Acid SCHEMBL4160622 | 0.85 | PADI4 (0.39) | CES1HDAC1HDAC2PTPN1PADI1 | |
| SCHEMBL4156447 | 0.82 | CES1 (0.59) | CES1HDAC1HDAC2PADI1PADI4 | |
| SCHEMBL4158065 | 0.82 | CES1 (0.45) | CES1HDAC1HDAC2NPY1RCNR2 | |
| SCHEMBL4605614 | 0.82 | CES1 (0.45) | CES1HDAC1HDAC2NPY1RCNR2 | |
| SCHEMBL4606734 | 0.81 | NPY1R (0.46) | CES1HDAC1HDAC2NPY1RPOLB | |
| SCHEMBL4169033 | 0.80 | CES1 (0.52) | CES1HDAC1HDAC2CNR2 | |
| Trifluoroacetic Acid SCHEMBL4304781 | 0.78 | CES1 (0.50) | CES1HDAC1HDAC2CNR2 | |
| SCHEMBL9203772 | 0.77 | ITGB3 (0.54) | PTPN1NPY1RCNR2CHRNA1CHRNG | |
| Trifluoroacetic Acid SCHEMBL4606072 | 0.76 | SIGMAR1 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090054448-A1 | Amino Acid Derivatives as Histone Deacetylase (HDAC) Inhibitors | JONES PHILIP | 2009-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054448-A1 | Amino Acid Derivatives as Histone Deacetylase (HDAC) Inhibitors | HDAC5, HDAC1, HDAC11 | CES1 1925/4885HDAC1 2/4885HDAC2 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.