Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | L3MBTL3 | Q96JM7 | 5/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.39 |
| ▸ | PREP | P48147 | 2/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | MBTD1 | Q05BQ5 | 2/20 | 0.33 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.33 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4162004 | 1.00 | HSD11B1 (0.43) | HSD11B1L3MBTL3L3MBTL1PREPCHRM2 | |
| SCHEMBL14371565 | 0.98 | HSD11B1 (0.43) | HSD11B1L3MBTL3L3MBTL1PREPCHRM2 | |
| SCHEMBL132146 | 0.88 | HSD11B1 (0.42) | HSD11B1L3MBTL3L3MBTL1PREPCHRM2 | |
| SCHEMBL31701244 | 0.87 | HSD11B1 (0.41) | HSD11B1PREPCHRM2CHRM1CHRM3 | |
| SCHEMBL31334346 | 0.87 | HSD11B1 (0.41) | HSD11B1PREPCHRM2CHRM1CHRM3 | |
| SCHEMBL12731249 | 0.86 | HSD11B1 (0.43) | HSD11B1PREPCHRM2CHRM1CHRM3 | |
| SCHEMBL15685555 | 0.86 | HSD11B1 (0.43) | HSD11B1PREPCHRM2CHRM1CHRM3 | |
| SCHEMBL12731246 | 0.86 | HSD11B1 (0.43) | HSD11B1PREPCHRM2CHRM1CHRM3 | |
| SCHEMBL12731687 | 0.86 | HSD11B1 (0.43) | HSD11B1PREPCHRM2CHRM1CHRM3 | |
| SCHEMBL24700252 | 0.84 | HSD11B1 (0.44) | HSD11B1L3MBTL3L3MBTL1PREPCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090093474-A1 | THIAZOLYL-DIHYDRO-INDAZOLE | GRAUERT MATTHIAS | 2009-04-09 | — | — | US | disclosed |
| US-20070238718-A1 | THIAZOLYL-DIHYDRO-INDAZOLE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-10-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090093474-A1 | THIAZOLYL-DIHYDRO-INDAZOLE | CYP3A43, CYP3A5, UGT1A3 | HSD11B1 55/4885L3MBTL3 2840/4885L3MBTL1 3059/4885 |
| US-20070238718-A1 | THIAZOLYL-DIHYDRO-INDAZOLE | CYP3A43, CYP3A5, UGT1A3 | HSD11B1 55/4885L3MBTL3 2840/4885L3MBTL1 3059/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.