Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | XDH | P47989 | 3/20 | 0.48 |
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.48 |
| ▸ | BRAF | P15056 | 2/20 | 0.48 |
| ▸ | SYK | P43405 | 2/20 | 0.47 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.47 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.46 |
| ▸ | CCND1 | P24385 | 1/20 | 0.46 |
| ▸ | CCNC | P24863 | 1/20 | 0.46 |
| ▸ | CDK8 | P49336 | 1/20 | 0.46 |
| ▸ | CDK7 | P50613 | 1/20 | 0.46 |
| ▸ | CDK9 | P50750 | 1/20 | 0.46 |
| ▸ | CCNH | P51946 | 1/20 | 0.46 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.46 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 6/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4187491 | 0.88 | XDH (0.57) | XDHSLC22A12BRAFSYKSIRT2 | |
| SCHEMBL4191929 | 0.86 | XDH (0.61) | PARP1XDHSLC22A12BRAFSYK | |
| SCHEMBL4154769 | 0.86 | PARP1 (0.50) | PARP1XDHSLC22A12BRAFSYK | |
| SCHEMBL21311940 | 0.85 | FYN (0.53) | XDHSLC22A12BRAFSYKFYN | |
| SCHEMBL4182331 | 0.83 | SIRT2 (0.71) | XDHSLC22A12SYKSIRT2SIRT1 | |
| SCHEMBL4199231 | 0.82 | XDH (0.57) | PARP1XDHSLC22A12SYKSIRT2 | |
| SCHEMBL4194432 | 0.82 | TSHR (0.54) | SYKABL1EGFRGSK3AGSK3B | |
| SCHEMBL4143243 | 0.81 | FYN (0.57) | PARP1SYKCCNT1CCND1CCNC | |
| SCHEMBL4191642 | 0.80 | XDH (0.61) | XDHSLC22A12SYKSIRT2SIRT1 | |
| SCHEMBL4199153 | 0.80 | ABL1 (0.48) | PARP1XDHSLC22A12SYKSIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090163515-A1 | Compounds Which Bind to the Active Site of Protein Kinase Enzymes | BIOFOCUS DISCOVERY LTD. | 2009-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163515-A1 | Compounds Which Bind to the Active Site of Protein Kinase Enzymes | ROCK1, ROCK2, CIT | PARP1 1375/4885XDH 750/4885SLC22A12 4511/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.