Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.54 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.54 |
| ▸ | AURKA | O14965 | 2/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | AKT2 | P31751 | 2/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
| ▸ | HTR6 | P50406 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3718343 | 0.98 | CHEK1 (0.53) | CHEK1CHEK2AURKACHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL3720255 | 0.81 | PLK4 (0.44) | CHEK1CHEK2PLK4PAK4ADRB2 | |
| Hydrochloric Acid SCHEMBL3723324 | 0.81 | ADRB2 (0.53) | CHEK1CHEK2CHRNB2CHRNA4PLK4 | |
| SCHEMBL3718717 | 0.78 | EPHX2 (0.43) | CHEK1CHEK2PLK4PAK4ADRB2 | |
| SCHEMBL3736680 | 0.78 | AKT2 (0.41) | CHEK1CHEK2PLK4PAK4ADRB2 | |
| SCHEMBL3721308 | 0.78 | HTR2C (0.55) | AURKACHRNB2CHRNA4HTR6HTR2C | |
| Hydrochloric Acid SCHEMBL3716007 | 0.77 | ROCK2 (0.42) | CHEK1CHEK2PLK4PAK4ADRB2 | |
| Hydrochloric Acid SCHEMBL3713877 | 0.77 | ADRB2 (0.43) | CHEK1CHEK2PLK4PAK4ADRB2 | |
| Hydrochloric Acid SCHEMBL3721311 | 0.77 | AKT2 (0.40) | CHEK1CHEK2PLK4PAK4ADRB2 | |
| Hydrochloric Acid SCHEMBL3721934 | 0.77 | AKT2 (0.40) | CHEK1CHEK2PLK4PAK4ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009089359-A1 | PYRAZOLOPYRIDINES AS KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2009-07-16 | — | — | WO | disclosed |