Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | TACR1 | P25103 | 2/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4165131 | 1.00 | CCR2 (0.38) | CCR2NPSR1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3647588 | 1.00 | CCR2 (0.38) | CCR2NPSR1CYP1A2CYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL3642470 | 0.99 | CCR2 (0.37) | CCR2NPSR1CYP1A2CYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL3642473 | 0.99 | CCR2 (0.37) | CCR2NPSR1CYP1A2CYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL3642476 | 0.99 | CCR2 (0.37) | CCR2NPSR1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3644833 | 0.85 | TACR1 (0.44) | TACR1UTS2RTP53MCHR1 | |
| SCHEMBL3648595 | 0.85 | TACR1 (0.44) | TACR1UTS2RTP53MCHR1 | |
| SCHEMBL3644830 | 0.85 | TACR1 (0.44) | TACR1UTS2RTP53MCHR1 | |
| SCHEMBL3647718 | 0.82 | PDE2A (0.38) | CCR2TACR1UTS2RRORCMCHR1 | |
| SCHEMBL3645762 | 0.82 | PDE2A (0.38) | CCR2TACR1UTS2RRORCMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090036422-A1 | MONOAMIDE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036422-A1 | MONOAMIDE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | HCRTR2, HCRTR1, MTNR1A | CCR2 1224/4885NPSR1 7/4885CYP1A2 673/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.