Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 13/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 12/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27786939 | 0.89 | NR1H2 (0.46) | NR1H2NR1H3SCN9AATM | |
| SCHEMBL28780848 | 0.85 | NR1H2 (0.39) | NR1H2NR1H3ATMPIK3CD | |
| SCHEMBL4165748 | 0.85 | SCN9A (0.46) | NR1H2NR1H3SCN9AALOX5APFEN1 | |
| SCHEMBL27765402 | 0.83 | NR1H2 (0.40) | NR1H2NR1H3ATMPIK3CD | |
| SCHEMBL27765245 | 0.83 | NR1H2 (0.46) | NR1H2NR1H3SCN9AALOX5APFEN1 | |
| SCHEMBL4165443 | 0.82 | NR1H2 (0.44) | NR1H2NR1H3ATMPIK3CD | |
| SCHEMBL4166168 | 0.82 | NR1H2 (0.48) | NR1H2NR1H3SCN9A | |
| SCHEMBL28780850 | 0.80 | NR1H2 (0.41) | NR1H2NR1H3ATM | |
| SCHEMBL27765403 | 0.79 | NR1H2 (0.40) | NR1H2NR1H3 | |
| SCHEMBL4174648 | 0.78 | NR1H2 (0.46) | NR1H2NR1H3SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101541751-A | Quinoline compounds | WYETH CORP (US) | 2009-09-23 | — | — | CN | claimed |
| CN-101541751-A | Quinoline compounds | WYETH CORP (US) | 2009-09-23 | — | — | CN | disclosed |
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | disclosed |