Sugi Predict

Sugi Predict / Compounds / SCHEMBL4165669

SCHEMBL4165669

SCHEMBL4165669

Cc1cc(Nc2cncc(Nc3ccc(Cl)c(NC(=O)C(C)C)c3)n2)n[nH]1

nearest known ligand 0.47

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 2/20 0.47
▸ ALDH1A1 P00352 2/20 0.47
▸ KMT2A Q03164 2/20 0.47
▸ JAK2 O60674 2/20 0.46
▸ JAK3 P52333 2/20 0.46
▸ IGF1R P08069 3/20 0.46
▸ AURKA O14965 8/20 0.42
▸ LMNA P02545 1/20 0.41
▸ AURKB Q96GD4 6/20 0.39
▸ NPC1 O15118 1/20 0.38
▸ GAA P10253 1/20 0.38
▸ RAB9A P51151 1/20 0.38
▸ SMN1; SMN2 Q16637 1/20 0.38
▸ DHODH Q02127 1/20 0.37
▸ SYK P43405 1/20 0.37
▸ PLK4 O00444 1/20 0.37
▸ NTRK1 P04629 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4015863 0.90 JAK2 (0.48) MEN1ALDH1A1KMT2AJAK2JAK3
SCHEMBL4165887 0.89 JAK2 (0.42) MEN1ALDH1A1KMT2AJAK2JAK3
SCHEMBL4171530 0.89 IGF1R (0.48) JAK2JAK3IGF1RAURKAAURKB
SCHEMBL4156999 0.87 TNIK (0.43) MEN1KMT2AJAK2JAK3IGF1R
SCHEMBL4013576 0.86 NPC1 (0.44) MEN1KMT2AJAK2JAK3AURKA
SCHEMBL13663525 0.84 JAK3 (0.53) MEN1KMT2AJAK2JAK3IGF1R
SCHEMBL4177008 0.83 RAB9A (0.46) MEN1ALDH1A1KMT2AIGF1RAURKA
SCHEMBL4161679 0.82 AURKA (0.49) JAK2JAK3IGF1RAURKAAURKB
SCHEMBL4161569 0.82 ROCK2 (0.51) MEN1KMT2AJAK2JAK3IGF1R
SCHEMBL13663558 0.80 AURKA (0.54) MEN1ALDH1A1KMT2AJAK2JAK3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090270418-A1 PYRAZOLE PYRAZINE AMINE COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS THEREOF AND METHODS OF TREATMENT THEREWITH SIGNAL PHARMACEUTICALS, LLC 2009-10-29 — — US claimed
WO-2009089042-A1 PYRAZOLE PYRAZINE AMINE COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS THEREOF AND METHODS OF TREATMENT THEREWITH SIGNAL PHARMACEUTICALS, LLC (US) 2009-07-16 — — WO claimed
US-20090270418-A1 PYRAZOLE PYRAZINE AMINE COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS THEREOF AND METHODS OF TREATMENT THEREWITH SIGNAL PHARMACEUTICALS, LLC 2009-10-29 — — US disclosed
US-20090270418-A1 PYRAZOLE PYRAZINE AMINE COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS THEREOF AND METHODS OF TREATMENT THEREWITH SIGNAL PHARMACEUTICALS, LLC 2009-10-29 — — US disclosed
US-20090270418-A1 PYRAZOLE PYRAZINE AMINE COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS THEREOF AND METHODS OF TREATMENT THEREWITH SIGNAL PHARMACEUTICALS, LLC 2009-10-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090270418-A1 PYRAZOLE PYRAZINE AMINE COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS THEREOF AND METHODS OF TREATMENT THEREWITH MAP3K1, MAP3K15, MAP3K5 MEN1 3321/4885ALDH1A1 4322/4885KMT2A 844/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.