Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3811645 | 0.86 | LMNA (0.49) | LMNAALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL5442506 | 0.86 | LMNA (0.51) | LMNAALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL4889016 | 0.83 | KDM4E (0.39) | LMNAALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL4186260 | 0.77 | KDM4E (0.41) | LMNAALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL14529462 | 0.75 | CYP1A2 (0.44) | LMNAALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL4136851 | 0.74 | KDM4E (0.54) | LMNAALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL4136849 | 0.74 | KDM4E (0.54) | LMNAALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL3814595 | 0.73 | KMT2A (0.44) | LMNAALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL3810010 | 0.73 | KMT2A (0.44) | LMNAALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL6724048 | 0.73 | LMNA (0.52) | LMNAALDH1A1KDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090062218-A1 | MACROLONE COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2009-03-05 | — | — | US | disclosed |
| US-20080096829-A1 | Macrolone Compounds | GLAXO GROUP LIMITED (GB) | 2008-04-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090062218-A1 | MACROLONE COMPOUNDS | CYP51A1, MRPL21, MYD88 | LMNA 1055/4885ALDH1A1 4011/4885KDM4E 3897/4885 |
| US-20080096829-A1 | Macrolone Compounds | MRPL21, MRPS18A, MRPL19 | LMNA 896/4885ALDH1A1 3772/4885KDM4E 4136/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.