Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.34 |
| ▸ | ALB | P02768 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3982534 | 0.85 | KDM4E (0.44) | KDM4ESMN1; SMN2CYP1A2ADRA2BMAPK1 | |
| SCHEMBL11258443 | 0.84 | KDM4E (0.44) | KDM4ESMN1; SMN2CYP1A2ADRA2BMAPK1 | |
| SCHEMBL4889016 | 0.84 | KDM4E (0.39) | KDM4ESMN1; SMN2CYP1A2ADRA2BMAPK1 | |
| SCHEMBL3811645 | 0.82 | LMNA (0.49) | KDM4ECYP1A2MAPK1ALDH1A1HPGD | |
| SCHEMBL11744513 | 0.81 | ACHE (0.46) | KDM4ESMN1; SMN2CYP1A2ADRA2BMAPK1 | |
| SCHEMBL8039755 | 0.78 | HTR2A (0.49) | KDM4ECYP1A2ALDH1A1HPGDHSD17B10 | |
| SCHEMBL3813096 | 0.77 | KDM4E (0.41) | KDM4ESMN1; SMN2CYP1A2ADRA2BMAPK1 | |
| SCHEMBL4131074 | 0.76 | KDM4E (0.74) | KDM4ESMN1; SMN2CYP1A2ALDH1A1HPGD | |
| SCHEMBL4131070 | 0.76 | KDM4E (0.74) | KDM4ESMN1; SMN2CYP1A2ALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL3977815 | 0.76 | KDM4E (0.40) | KDM4ESMN1; SMN2CYP1A2ADRA2BMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090170791-A1 | MACROLONES | GLAXO SMITH KLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O A CORPORATION | 2009-07-02 | — | — | US | disclosed |
| US-20090170791-A1 | MACROLONES | GLAXO SMITH KLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O A CORPORATION | 2009-07-02 | — | — | US | disclosed |
| US-20090170791-A1 | MACROLONES | GLAXO SMITH KLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O A CORPORATION | 2009-07-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090170791-A1 | MACROLONES | CYP51A1, MRPL21, LSS | KDM4E 4180/4885SMN1; SMN2 1511/4885CYP1A2 126/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.