Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 8/20 | 0.49 |
| ▸ | AKR1B1 | P15121 | 6/20 | 0.48 |
| ▸ | AKR1A1 | P14550 | 2/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 2/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | MMP14 | P50281 | 1/20 | 0.38 |
| ▸ | MMP17 | Q9ULZ9 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.35 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4167818 | 0.89 | AKR1B1 (0.46) | PTGDR2AKR1B1AKR1A1MMP2MMP3 | |
| SCHEMBL4164829 | 0.87 | AKR1B1 (0.41) | PTGDR2AKR1B1BACE1MEN1ALDH1A1 | |
| SCHEMBL4164837 | 0.86 | AKR1B1 (0.48) | PTGDR2AKR1B1AKR1A1MAPT | |
| SCHEMBL4170642 | 0.85 | AKR1B1 (0.42) | PTGDR2AKR1B1AKR1A1MMP2MMP3 | |
| SCHEMBL4166000 | 0.84 | HPGD (0.46) | PTGDR2AKR1B1AKR1A1ALDH1A1LMNA | |
| SCHEMBL4260787 | 0.84 | AKR1B1 (0.48) | PTGDR2AKR1B1AKR1A1MEN1USP2 | |
| SCHEMBL4261416 | 0.84 | AKR1B1 (0.48) | PTGDR2AKR1B1AKR1A1 | |
| SCHEMBL4163278 | 0.83 | AKR1B1 (0.44) | AKR1B1AKR1A1BACE1MEN1ALDH1A1 | |
| SCHEMBL4169748 | 0.81 | AKR1B1 (0.48) | PTGDR2AKR1B1AKR1A1MMP2MMP3 | |
| SCHEMBL4255684 | 0.81 | AKR1B1 (0.45) | PTGDR2AKR1B1AKR1A1MEN1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090076049-A1 | Novel Spiro [Imidazolidine-4, 3' -Indole] 2, 2', 5' (1H) Triones for Treatment of Conditions Associated with Vanilloid Receptor 1 | ASTRAZENECA AB (SE) | 2009-03-19 | — | — | US | claimed |
| US-20090076049-A1 | Novel Spiro [Imidazolidine-4, 3' -Indole] 2, 2', 5' (1H) Triones for Treatment of Conditions Associated with Vanilloid Receptor 1 | ASTRAZENECA AB (SE) | 2009-03-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090076049-A1 | Novel Spiro [Imidazolidine-4, 3' -Indole] 2, 2', 5' (1H) Triones for Treatment of Conditions Associated with Vanilloid Receptor 1 | TRPV1, TRPV5, TRPV2 | PTGDR2 172/4885AKR1B1 344/4885AKR1A1 310/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.