Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 13/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4164806 | 0.77 | KDM4E (0.36) | KDM4EALDH1A1GAARAB9ASMN1; SMN2 | |
| SCHEMBL6168006 | 0.77 | KDM4E (0.57) | KDM4EALDH1A1GAARAB9AL3MBTL1 | |
| SCHEMBL4160113 | 0.76 | MAPT (0.37) | KDM4EALDH1A1GAARAB9AL3MBTL1 | |
| SCHEMBL2412008 | 0.76 | CYP1A2 (0.54) | KDM4EALDH1A1RAB9ALMNASMN1; SMN2 | |
| SCHEMBL4154288 | 0.74 | HSD17B10 (0.43) | KDM4EALDH1A1GAARAB9ALMNA | |
| SCHEMBL4161913 | 0.74 | CCNC (0.36) | KDM4EALDH1A1GAARAB9AGLA | |
| SCHEMBL2076088 | 0.73 | NR4A2 (0.35) | KDM4EALDH1A1GAARAB9ALMNA | |
| SCHEMBL4167344 | 0.72 | ALDH1A1 (0.67) | KDM4EALDH1A1GAARAB9AL3MBTL1 | |
| SCHEMBL4167350 | 0.72 | NR4A2 (0.32) | HPGD | |
| SCHEMBL2075029 | 0.72 | JAK2 (0.42) | KDM4EALDH1A1RAB9AL3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090137572-A1 | 2-substituted-4-heteroaryl-pyrimidines useful for the treatment of proliferative disorders | CYCLACEL LIMITED (GB) | 2009-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137572-A1 | 2-substituted-4-heteroaryl-pyrimidines useful for the treatment of proliferative disorders | CDK2, CDK4, CDK20 | KDM4E 2234/4885ALDH1A1 2743/4885GAA 1172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.