Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 13/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 5/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10091957 | 0.78 | KDM4E (0.61) | KDM4EALDH1A1GAARAB9AL3MBTL1 | |
| SCHEMBL288142 | 0.77 | KDM4E (0.54) | KDM4EALDH1A1GAARAB9AL3MBTL1 | |
| SCHEMBL4167341 | 0.77 | KDM4E (0.53) | KDM4EALDH1A1GAARAB9AL3MBTL1 | |
| SCHEMBL1960860 | 0.75 | SMN1; SMN2 (0.56) | KDM4EALDH1A1GAARAB9AL3MBTL1 | |
| SCHEMBL27016991 | 0.75 | KDM4E (0.58) | KDM4EALDH1A1GAARAB9AL3MBTL1 | |
| SCHEMBL288141 | 0.73 | KDM4E (0.78) | KDM4EALDH1A1GAARAB9AL3MBTL1 | |
| SCHEMBL3418775 | 0.73 | KDM4E (1.00) | KDM4EALDH1A1GAARAB9AL3MBTL1 | |
| SCHEMBL18873086 | 0.72 | KDM4E (0.51) | KDM4EALDH1A1GAARAB9AL3MBTL1 | |
| SCHEMBL3059795 | 0.72 | KDM4E (0.76) | KDM4EALDH1A1GAARAB9AL3MBTL1 | |
| SCHEMBL12641921 | 0.71 | RAB9A (0.54) | KDM4EALDH1A1GAARAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1513837-A1 | THIAZOLE DERIVATIVES AS PHOSPHODIESTERASE IV INHIBITORS | MERCK PATENT GmbH (DE) | 2005-03-16 | — | — | EP | claimed |
| WO-2004000839-A1 | THIAZOLE DERIVATIVES AS PHOSPHODIESTERASE IV INHIBITORS | MERCK PATENT GMBH (DE) | 2003-12-31 | — | — | WO | claimed |