SCHEMBL416839

SCHEMBL416839

c1cn2nccc2nn1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19173 0.68
SCHEMBL312692 0.67
Hydrochloric Acid SCHEMBL6894527 0.67 PDE10A (0.45)
SCHEMBL31338725 0.67 PDE10A (0.45)
SCHEMBL31674379 0.67 PDE10A (0.45)
SCHEMBL15830149 0.67
SCHEMBL1440869 0.65 DYRK1A (0.49)
SCHEMBL5435761 0.64 DYRK1A (0.61)
SCHEMBL14432725 0.64 TGFBR1 (0.35)
SCHEMBL4789377 0.64 DYRK1A (0.47)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 330 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210220408-A1 ARYL HYDROCARBON RECEPTOR ANTAGONISTS AND METHODS OF USE EDIGENE BIOTECHNOLOGY, INC. (CN) 2021-07-22 US claimed
EP-3847159-A2 ARYL HYDROCARBON RECEPTOR ANTAGONISTS AND METHODS OF USE Magenta Therapeutics, Inc. (US) 2021-07-14 EP claimed
EP-3078738-B1 WNT PATHWAY STIMULATION IN REPROGRAMMING SOMATIC CELLS WHITEHEAD INST BIOMEDICAL RES (US) 2020-05-20 EP claimed
WO-2011033094-A1 SCHEDULE OF ADMINISTRATION OF BENZAZOLE DERIVATIVES IN THE TREATMENT OF LEUKEMIAS 4SC AG (DE) 2011-03-24 WO claimed
EP-1996583-A1 THIAZOLES AS NF-KB INHIBITORS (PROTEASOME INHIBITORS) 4SC AG (DE) 2008-12-03 EP claimed
WO-2007104558-A1 THIAZOLES AS NF-KB INHIBITORS (PROTEASOME INHIBITORS) 4SC AG (DE) 2007-09-20 WO claimed
US-20070219190-A1 Heterocyclic NF-kB Inhibitors 4SC AG (DE) 2007-09-20 US claimed
EP-1834954-A1 Thiazoles as NF-kB Inhibitors (proteasome inhibitors) 4SC AG (DE) 2007-09-19 EP claimed
US-12497568-B2 Upgrading of bio-oil using ammonia UNIVERSITY OF SOUTH CAROLINA (US) 2025-12-16 US disclosed
US-20250243190-A1 NEW DEUTERATED RORGAMMA/RORGAMMAT INVERSE AGONISTS IMMUNIC AG (DE) 2025-07-31 US disclosed
US-12351822-B2 Stem cell culture systems for columnar epithelial stem cells, and uses related thereto UNIVERSITY OF HOUSTON SYSTEM (US) 2025-07-08 US disclosed
EP-4508049-A1 DEUTERATED RORGAMMA/RORGAMMAT INVERSE AGONISTS Immunic AG (DE) 2025-02-19 EP disclosed
US-20240368145-A1 METHODS FOR TREATING CANCER IMMUNIC AG (DE) 2024-11-07 US disclosed
US-20240360156-A1 HETEROCYCLIC COMPOUND AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2024-10-31 US disclosed
US-6960583-B2 Pyrazolotriazines as CRF antagonists BRISTOL-MYERS SQUIBB COMPANY (US) 2005-11-01 US disclosed
US-20040176376-A1 Pyrazolotriazines as CRF antagonists BRISTOL-MYERS SQUIBB PHARMA COMPANY 2004-09-09 US disclosed
US-6730465-B2 Color photographic element containing a heterocyclic dye-forming coupler EASTMAN KODAK COMPANY 2004-05-04 US disclosed
US-20030207219-A1 Color photographic element containing a heterocyclic dye-forming coupler EASTMAN KODAK COMPANY 2003-11-06 US disclosed
EP-1345077-A2 Colour photographic element containing a heterocyclic dye-forming coupler EASTMAN KODAK COMPANY (US) 2003-09-17 EP disclosed
US-20020147338-A1 Pyrazolotriazines as CRF antagonists BRISTOL-MYERS SQUIBB PHARMA COMPANY 2002-10-10 US disclosed