⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4300004 | 0.76 | CTSS (0.53) | — | |
| SCHEMBL416839 | 0.67 | — | — | |
| SCHEMBL11153743 | 0.66 | FYN (0.54) | — | |
| SCHEMBL5806164 | 0.64 | TDP1 (0.54) | — | |
| SCHEMBL11156049 | 0.64 | KMT2A (0.55) | — | |
| SCHEMBL10764435 | 0.64 | KDM4E (0.59) | — | |
| SCHEMBL1426882 | 0.64 | KDM4E (1.00) | — | |
| SCHEMBL20160363 | 0.64 | KDM4E (0.59) | — | |
| SCHEMBL2736703 | 0.64 | KDM4E (0.59) | — | |
| SCHEMBL46494 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 854 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120118077-A | Compound and application thereof | 润尔眼科药物（广州）有限公司 | 2025-06-10 | — | — | CN | claimed |
| US-20240277708-A1 | Use of [1,2,4] Triazolo [4,3-B] Pyridazine Derivative For Preventing and Treating Senescence and Senescence-Related Diseases | THE EIGHTH AFFILIATED HOSPITAL, SUN YAT-SEN UNIVERSITY (CN) | 2024-08-22 | — | — | US | claimed |
| WO-2024164543-A1 | USE OF [1,2,4]TRIAZOLO[4,3-B]PYRIDAZINE DERIVATIVE IN PREVENTION AND TREATMENT OF AGING AND AGING-RELATED DISEASES | 中山大学附属第八医院（深圳福田） | 2024-08-15 | — | — | WO | claimed |
| EP-4413986-A1 | USE OF [1,2,4] TRIAZOLO [4,3-B] PYRIDAZINE DERIVATIVE FOR PREVENTING AND TREATING SENESCENCE AND SENESCENCE-RELATED DISEASES | The Eight Affiliated Hospital, Sun Yat-Sen University (CN) | 2024-08-14 | — | — | EP | claimed |
| CN-116421607-A | Application of 1,2,4 triazolo 4,3-B pyridazine derivative in preparation of anti-idiopathic pulmonary fibrosis drugs | 中山大学附属第八医院（深圳福田） | 2023-07-14 | — | — | CN | claimed |
| CN-116236485-A | Application of 1,2,4 triazolo 4,3-B pyridazine derivative in preparation of anti-hepatic fibrosis drugs | 中山大学附属第八医院（深圳福田） | 2023-06-09 | — | — | CN | claimed |
| CN-115813920-B | Application of 1,2,4 triazolo 4,3-B pyridazine derivative in preparation of medicines for treating chronic kidney disease | 中山大学附属第八医院（深圳福田） | 2023-04-25 | — | — | CN | claimed |
| CN-115837022-B | Application of 1,2, 4-triazolo 4,3-B pyridazine derivative in preparation of anti-aging drugs | 中山大学附属第八医院（深圳福田） | 2023-04-25 | — | — | CN | claimed |
| CN-115837022-A | Application of 1,2,4 triazolo 4,3-B pyridazine derivative in preparation of anti-aging drugs | 中山大学附属第八医院（深圳福田） | 2023-03-24 | — | — | CN | claimed |
| CN-115813920-A | Use of 1,2,4 triazolo 4,3-B pyridazine derivatives in the treatment of chronic kidney disease | 中山大学附属第八医院（深圳福田） | 2023-03-21 | — | — | CN | claimed |
| US-20040152659-A1 | Method for the treatment of parkinson's disease comprising administering an A1A2a receptor dual antagonist | FUJISAWA PHARMACEUTICAL CO. LTD. (JP) | 2004-08-05 | — | — | US | claimed |
| EP-1177797-A9 | NOVEL USE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-05-15 | — | — | EP | claimed |
| EP-1177797-A1 | NOVEL USE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-02-06 | — | — | EP | claimed |
| WO-1999025353-A1 | THERAPEUTIC USES OF TRIAZOLO-PYRIDAZINE DERIVATIVES | MERCK SHARP & DOHME LIMITED (GB) | 1999-05-27 | — | — | WO | claimed |
| EP-0745154-B1 | MULTICOMPONENT SYSTEM FOR MODIFYING, DECOMPOSING OR BLEACHING LIGNIN, LIGNIN-CONTAINING MATERIALS OR SIMILAR SUBSTANCES AND METHOD OF USING THIS SYSTEM | LIGNOZYM GMBH (DE) | 1998-09-16 | — | — | EP | claimed |
| EP-0483027-A2 | Triazolopyridazines, methods for their preparation, their use as herbicides and intermediates | RHONE-POULENC AGROCHIMIE (FR) | 1992-04-29 | — | — | EP | claimed |
| US-4871653-A | DEVELOPING IN PRESENCE OF MERCAPTO POLYAZAINDENE PROMOTERS AND NUCLEATING QUATERNARY OR HYDRAZIDE-TYPE COMPOUNDS | FUJI PHOTO FILM CO., LTD. (JP) | 1989-10-03 | — | — | US | claimed |
| US-4810705-A | BENZODIAZEPINE DERIVATIVE ANTAGONISTS | SANOFI (FR) | 1989-03-07 | — | — | US | claimed |
| EP-0156734-A2 | Triazolo[4,3-b]pyridazines, process for their preparation and pharmaceutical compositions containing them | SANOFI S.A. (FR) | 1985-10-02 | — | — | EP | claimed |
| US-4125611-A | MICROBIOCIDES | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1978-11-14 | — | — | US | claimed |