Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 10/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 10/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 9/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 9/20 | 0.55 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 9/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 8/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 8/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 8/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | NAAA | Q02083 | 1/20 | 0.48 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | KDM5A | P29375 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29756120 | 0.98 | HDAC3 (0.56) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL22190364 | 0.94 | HDAC1 (0.58) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL4167123 | 0.88 | HPGD (0.66) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL4173154 | 0.85 | HPGD (0.62) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL5528083 | 0.82 | HPGD (0.50) | HPGDP2RX7NPC1RAB9ANAAA | |
| SCHEMBL8391858 | 0.82 | NPC1 (0.50) | HPGDP2RX7NPC1RAB9ANAAA | |
| SCHEMBL8353488 | 0.82 | NPC1 (0.50) | HPGDP2RX7NPC1RAB9ANAAA | |
| SCHEMBL24673607 | 0.81 | HPGD (0.79) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL8290227 | 0.81 | GLA (0.57) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL19255255 | 0.81 | HPGD (0.79) | HDAC3HDAC1HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111566116-B | Novel metal complex, process for producing the same, and process for producing gamma-lactam compound using the same | 基础科学研究院 | 2023-06-09 | — | — | CN | disclosed |
| CN-111566116-A | Novel metal complex, method for producing same, and method for producing gamma-lactam compound using same | 基础科学研究院 | 2020-08-21 | — | — | CN | disclosed |
| US-8227516-B2 | Compounds as histone deacetylase inhibitors | 4SC DISCOVERY GMBH (DE) | 2012-07-24 | — | — | US | disclosed |
| US-8227516-B2 | Compounds as histone deacetylase inhibitors | 4SC DISCOVERY GMBH (DE) | 2012-07-24 | — | — | US | disclosed |
| US-8227516-B2 | Compounds as histone deacetylase inhibitors | 4SC DISCOVERY GMBH (DE) | 2012-07-24 | — | — | US | disclosed |
| US-20120135091-A1 | METHODS AND COMPOSITIONS FOR ENHANCING LIFESPAN INVOLVING SIRTUIN-MODULATING COMPOUNDS AND CHALCOGENIDES | US ARMY, SECRETARY OF THE ARMY | 2012-05-31 | — | — | US | disclosed |
| US-20090088478-A1 | NOVEL COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | 4SC DISCOVERY GMBH (DE) | 2009-04-02 | — | — | US | disclosed |
| US-20090088478-A1 | NOVEL COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | 4SC DISCOVERY GMBH (DE) | 2009-04-02 | — | — | US | disclosed |
| US-20090088478-A1 | NOVEL COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | 4SC DISCOVERY GMBH (DE) | 2009-04-02 | — | — | US | disclosed |
| US-7465719-B2 | Carbamic acid compounds comprising an ester or ketone linkage as HDAC inhibitors | TOPOTARGET UK LIMITED (GB) | 2008-12-16 | — | — | US | disclosed |
| WO-2008089439-A2 | METHODS AND COMPOSITIONS FOR ENHANCING LIFESPAN INVOLVING SIRTUIN-MODULATING COMPOUNDS AND CHALCOGENIDES | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 2008-07-24 | — | — | WO | disclosed |
| US-20050176686-A1 | Novel compounds as histone deacetylase inhibitors | 4SC AG (DE) | 2005-08-11 | — | — | US | disclosed |
| EP-1523470-A1 | NOVEL COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | 4SC AG (DE) | 2005-04-20 | — | — | EP | disclosed |
| WO-2004009536-A1 | NOVEL COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | 4SC AG (DE) | 2004-01-29 | — | — | WO | disclosed |
| WO-2004009536-A1 | NOVEL COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | 4SC AG (DE) | 2004-01-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050176686-A1 | Novel compounds as histone deacetylase inhibitors | HDAC3, HDAC1, HDAC2 | HDAC3 1/4885HDAC1 2/4885HDAC2 3/4885 |
| US-20090088478-A1 | NOVEL COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | HDAC1, HDAC11, HDAC5 | HDAC3 7/4885HDAC1 1/4885HDAC2 5/4885 |
| US-20120135091-A1 | METHODS AND COMPOSITIONS FOR ENHANCING LIFESPAN INVOLVING SIRTUIN-MODULATING COMPOUNDS AND CHALCOGENIDES | HSF1, SIRT1, SIRT2 | HDAC3 43/4885HDAC1 32/4885HDAC2 44/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.