Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.50 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | ALPL | P05186 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4167123 | 0.98 | HPGD (0.66) | HPGDHDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL29756120 | 0.87 | HDAC3 (0.56) | HPGDHDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL4170376 | 0.85 | HDAC3 (0.55) | HPGDHDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL11331863 | 0.85 | HPGD (0.56) | HPGDHDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL22190364 | 0.84 | HDAC1 (0.58) | HPGDHDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL6392074 | 0.80 | HPGD (0.60) | HPGDGAAALDH1A1NPC1RAB9A | |
| SCHEMBL27586344 | 0.79 | HPGD (0.50) | HPGDGAAALDH1A1NPC1RAB9A | |
| SCHEMBL10568275 | 0.78 | HPGD (0.63) | HPGDGAAALDH1A1NPC1RAB9A | |
| SCHEMBL5245833 | 0.78 | HPGD (0.63) | HPGDGAAALDH1A1NPC1RAB9A | |
| SCHEMBL20372840 | 0.78 | HPGD (0.63) | HPGDGAAALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8227516-B2 | Compounds as histone deacetylase inhibitors | 4SC DISCOVERY GMBH (DE) | 2012-07-24 | — | — | US | claimed |
| US-20160378912-A1 | STRUCTURE-BASED MODELING AND TARGET-SELECTIVITY PREDICTION | EPIGENETX LLC (US) | 2016-12-29 | — | — | US | disclosed |
| US-20160378912-A1 | STRUCTURE-BASED MODELING AND TARGET-SELECTIVITY PREDICTION | EPIGENETX LLC (US) | 2016-12-29 | — | — | US | disclosed |
| WO-2015002860-A1 | STRUCTURE-BASED MODELING AND TARGET-SELECTIVITY PREDICTION | EPIGENETX, LLC (US) | 2015-01-08 | — | — | WO | disclosed |
| US-8227516-B2 | Compounds as histone deacetylase inhibitors | 4SC DISCOVERY GMBH (DE) | 2012-07-24 | — | — | US | disclosed |
| US-8227516-B2 | Compounds as histone deacetylase inhibitors | 4SC DISCOVERY GMBH (DE) | 2012-07-24 | — | — | US | disclosed |
| US-8227516-B2 | Compounds as histone deacetylase inhibitors | 4SC DISCOVERY GMBH (DE) | 2012-07-24 | — | — | US | disclosed |
| US-20120135091-A1 | METHODS AND COMPOSITIONS FOR ENHANCING LIFESPAN INVOLVING SIRTUIN-MODULATING COMPOUNDS AND CHALCOGENIDES | US ARMY, SECRETARY OF THE ARMY | 2012-05-31 | — | — | US | disclosed |
| US-20110092447-A1 | USING INHIBITORS OF HISTONE DEACETYLASES FOR THE SUPPRESSION THERAPY OF INHERITED DISEASE PREDISPOSING CONDITIONS | HENTSCH BERND | 2011-04-21 | — | — | US | disclosed |
| US-20110092447-A1 | USING INHIBITORS OF HISTONE DEACETYLASES FOR THE SUPPRESSION THERAPY OF INHERITED DISEASE PREDISPOSING CONDITIONS | HENTSCH BERND | 2011-04-21 | — | — | US | disclosed |
| US-20090088478-A1 | NOVEL COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | 4SC DISCOVERY GMBH (DE) | 2009-04-02 | — | — | US | disclosed |
| US-20090088478-A1 | NOVEL COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | 4SC DISCOVERY GMBH (DE) | 2009-04-02 | — | — | US | disclosed |
| US-20090088478-A1 | NOVEL COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | 4SC DISCOVERY GMBH (DE) | 2009-04-02 | — | — | US | disclosed |
| WO-2008089439-A2 | METHODS AND COMPOSITIONS FOR ENHANCING LIFESPAN INVOLVING SIRTUIN-MODULATING COMPOUNDS AND CHALCOGENIDES | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 2008-07-24 | — | — | WO | disclosed |
| US-20070037738-A1 | Using Inhibitors of Histone Deacetylases for the Suppression Therapy of Inherited Disease Predisposing Conditions | TOPOTARGET GERMANY AG (DE) | 2007-02-15 | — | — | US | disclosed |
| US-20070037738-A1 | Using Inhibitors of Histone Deacetylases for the Suppression Therapy of Inherited Disease Predisposing Conditions | TOPOTARGET GERMANY AG (DE) | 2007-02-15 | — | — | US | disclosed |
| US-20050176686-A1 | Novel compounds as histone deacetylase inhibitors | 4SC AG (DE) | 2005-08-11 | — | — | US | disclosed |
| EP-1523470-A1 | NOVEL COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | 4SC AG (DE) | 2005-04-20 | — | — | EP | disclosed |
| WO-2004009536-A1 | NOVEL COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | 4SC AG (DE) | 2004-01-29 | — | — | WO | disclosed |
| WO-2004009536-A1 | NOVEL COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | 4SC AG (DE) | 2004-01-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050176686-A1 | Novel compounds as histone deacetylase inhibitors | HDAC3, HDAC1, HDAC2 | HPGD 1495/4885HDAC3 1/4885HDAC1 2/4885 |
| US-20110092447-A1 | USING INHIBITORS OF HISTONE DEACETYLASES FOR THE SUPPRESSION THERAPY OF INHERITED DISEASE PREDISPOSING CONDITIONS | HDAC1, HDAC10, HDAC11 | HPGD 182/4885HDAC3 10/4885HDAC1 1/4885 |
| US-20090088478-A1 | NOVEL COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | HDAC1, HDAC11, HDAC5 | HPGD 556/4885HDAC3 7/4885HDAC1 1/4885 |
| US-20120135091-A1 | METHODS AND COMPOSITIONS FOR ENHANCING LIFESPAN INVOLVING SIRTUIN-MODULATING COMPOUNDS AND CHALCOGENIDES | HSF1, SIRT1, SIRT2 | HPGD 141/4885HDAC3 43/4885HDAC1 32/4885 |
| US-20070037738-A1 | Using Inhibitors of Histone Deacetylases for the Suppression Therapy of Inherited Disease Predisposing Conditions | HDAC1, HDAC10, HDAC11 | HPGD 182/4885HDAC3 10/4885HDAC1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.