Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OTC | P00480 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 7/20 | 0.40 |
| ▸ | NOS1 | P29475 | 6/20 | 0.40 |
| ▸ | NOS3 | P29474 | 4/20 | 0.40 |
| ▸ | DDAH1 | O94760 | 3/20 | 0.39 |
| ▸ | BHMT | Q93088 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.34 |
| ▸ | NPY4R | P50391 | 3/20 | 0.34 |
| ▸ | NPY1R | P25929 | 2/20 | 0.34 |
| ▸ | NPY2R | P49146 | 2/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.34 |
| ▸ | GSR | P00390 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL3692892 | 0.96 | OTC (0.39) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL3475256 | 0.96 | OTC (0.39) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL4171389 | 0.95 | OTC (0.44) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL16179227 | 0.95 | OTC (0.44) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL27873762 | 0.95 | OTC (0.44) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL16179489 | 0.95 | OTC (0.44) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL15140178 | 0.95 | OTC (0.44) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL27438301 | 0.92 | OTC (0.43) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL29193380 | 0.92 | GSR (0.43) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL3633339 | 0.91 | OTC (0.42) | OTCNOS2NOS1NOS3DDAH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998058967-A1 | SELF-ASSEMBLING PEPTIDE SURFACES FOR CELL PATTERNING AND INTERACTIONS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1998-12-30 | — | — | WO | disclosed |