Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 11/20 | 0.47 |
| ▸ | PRPS1 | P60891 | 7/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | NPY1R | P25929 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4162361 | 0.92 | PRPS1 (0.41) | HRH4PRPS1JAK1NPY1R | |
| SCHEMBL4161537 | 0.88 | GPR119 (0.41) | HRH4 | |
| SCHEMBL602350 | 0.87 | HRH4 (0.62) | HRH4 | |
| SCHEMBL606087 | 0.82 | HRH4 (0.60) | HRH4PRPS1 | |
| SCHEMBL605439 | 0.81 | HRH4 (0.47) | HRH4PRPS1NPY1R | |
| SCHEMBL603867 | 0.80 | HRH4 (0.51) | HRH4 | |
| SCHEMBL12057121 | 0.80 | HRH4 (0.57) | HRH4PRPS1 | |
| SCHEMBL604413 | 0.80 | HRH4 (0.46) | HRH4PRPS1JAK1NPY1R | |
| SCHEMBL605908 | 0.79 | HRH4 (0.60) | HRH4PRPS1NPY1R | |
| SCHEMBL604047 | 0.78 | HRH4 (0.49) | HRH4PRPS1NPY1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8084466-B2 | Bicyclic heteroaryl-substituted imidazoles as modulators of the histamine H4 receptor | JANSSEN PHARMACEUTICA NV (BE) | 2011-12-27 | — | — | US | disclosed |
| US-20090156613-A1 | Bicyclic heteroaryl-substituted imidazoles as modulators of the histamine H4 receptor | KINDRACHUK DAVID E | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156613-A1 | Bicyclic heteroaryl-substituted imidazoles as modulators of the histamine H4 receptor | HRH4, HRH3, HRH1 | HRH4 1/4885PRPS1 3948/4885JAK1 1683/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.